Head to Head
| NHL Pre-Season | 2021/09/27 00:00 | ANA Ducks v SJ Sharks | L | 6-3 |
| NHL | 2021/04/15 02:30 | ANA Ducks v SJ Sharks | L | 4-1 |
| NHL | 2021/04/13 02:30 | ANA Ducks v SJ Sharks | L | 4-0 |
| NHL | 2021/04/07 02:30 | ANA Ducks v SJ Sharks | L | 5-1 |
| NHL | 2021/03/14 03:00 | SJ Sharks v ANA Ducks | W | 3-1 |
| NHL | 2021/03/13 03:00 | SJ Sharks v ANA Ducks | W | 6-0 |
| NHL | 2021/02/16 03:30 | ANA Ducks v SJ Sharks | W | 2-3 |
| NHL | 2021/02/07 03:00 | SJ Sharks v ANA Ducks | L | 1-2 |
Home History
| NHL Pre-Season | 2021/09/29 02:00 | LA Kings v SJ Sharks | L | 4-3 |
| NHL Pre-Season | 2021/09/27 02:00 | VGS Golden Knights v SJ Sharks | W | 2-4 |
| NHL Pre-Season | 2021/09/27 00:00 | ANA Ducks v SJ Sharks | L | 6-3 |
| NHL | 2021/05/13 01:00 | VGS Golden Knights v SJ Sharks | L | 6-0 |
| NHL | 2021/05/09 02:30 | ARZ Coyotes v SJ Sharks | L | 5-4 |
| NHL | 2021/05/08 02:30 | ARZ Coyotes v SJ Sharks | L | 5-2 |
| NHL | 2021/05/06 01:30 | COL Avalanche v SJ Sharks | W | 2-3 |
| NHL | 2021/05/04 02:30 | COL Avalanche v SJ Sharks | L | 5-4 |
Away History
| NHL Pre-Season | 2021/09/30 02:00 | ARZ Coyotes v ANA Ducks | L | 4-1 |
| NHL Pre-Season | 2021/09/27 00:00 | ANA Ducks v SJ Sharks | W | 6-3 |
| NHL | 2021/05/09 00:00 | ANA Ducks v MIN Wild | L | 3-4 |
| NHL | 2021/05/08 00:00 | ANA Ducks v MIN Wild | L | 3-4 |
| NHL | 2021/05/06 00:00 | ANA Ducks v STL Blues | W | 3-2 |
| NHL | 2021/05/04 00:00 | ANA Ducks v STL Blues | L | 1-3 |
| NHL | 2021/05/02 02:00 | LA Kings v ANA Ducks | W | 2-6 |
| NHL | 2021/05/01 02:00 | LA Kings v ANA Ducks | L | 2-1 |