[5] River Plate Asuncion 1-1 Guairena FC [9] 2021-10-03 00:15
Stadium: Estadio River Plate Round: 11
Referee: Carlos P. Benitez Home Manager: Celso Rafael Ayala Gavilan Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2021/07/25 21:15 | Guairena FC v River Plate Asuncion | W | 1-2 |
| Paraguay Division Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asuncion | D | 0-0 |
| Copa Sudamericana | 2021/04/08 22:15 | River Plate Asuncion v Guairena FC | W | 4-2 |
| Copa Sudamericana | 2021/03/18 22:15 | Guairena FC v River Plate Asuncion | W | 1-2 |
| Paraguay Division Profesional | 2021/03/05 21:15 | River Plate Asuncion v Guairena FC | L | 0-1 |
| Paraguay Division Profesional | 2020/11/10 23:45 | River Plate Asuncion v Guairena FC | L | 1-2 |
| Paraguay Division Profesional | 2020/08/12 20:00 | River Plate Asuncion v Guairena FC | W | 2-1 |
| Paraguay Division Profesional | 2020/01/25 21:00 | Guairena FC v River Plate Asuncion | L | 2-0 |
Home History
| Paraguay Division Profesional | 2021/09/26 22:00 | River Plate Asuncion v Olimpia Asuncion | L | 1-2 |
| Paraguay Cup | 2021/09/21 21:00 | Deportivo Karai Chive v River Plate Asuncion | W | 2-4 |
| Paraguay Division Profesional | 2021/09/18 00:15 | River Plate Asuncion v Libertad Asuncion | L | 0-1 |
| Paraguay Division Profesional | 2021/09/11 22:00 | Sportivo Luqueno v River Plate Asuncion | W | 0-2 |
| Paraguay Division Profesional | 2021/08/29 23:00 | River Plate Asuncion v Guarani Asuncion | L | 1-5 |
| Paraguay Division Profesional | 2021/08/22 21:00 | 12 de Octubre v River Plate Asuncion | D | 2-2 |
| Paraguay Cup | 2021/08/18 23:30 | Coronel Martinez Yuty v River Plate Asuncion | W | 0-2 |
| Paraguay Division Profesional | 2021/08/13 23:45 | River Plate Asuncion v Nacional Asuncion | W | 1-0 |
Away History
| Paraguay Division Profesional | 2021/09/27 00:15 | Guairena FC v Libertad Asuncion | W | 2-1 |
| Paraguay Division Profesional | 2021/09/20 00:15 | Guairena FC v Sportivo Luqueno | L | 1-2 |
| Paraguay Cup | 2021/09/16 21:00 | Guairena FC v Club Oriental Asuncion | W | 2-1 |
| Paraguay Division Profesional | 2021/09/12 00:15 | Guarani Asuncion v Guairena FC | L | 3-0 |
| Paraguay Division Profesional | 2021/08/30 23:30 | Guairena FC v 12 de Octubre | L | 0-1 |
| Paraguay Cup | 2021/08/24 23:30 | 24 de Setiembre v Guairena FC | W | 0-3 |
| Paraguay Division Profesional | 2021/08/20 23:30 | Nacional Asuncion v Guairena FC | W | 0-2 |
| Paraguay Division Profesional | 2021/08/13 21:30 | Guairena FC v Sol de America | D | 1-1 |