[10] Nis 2-3 Spartak Subotica [6] 2022-02-13 16:00
Stadium: Sport Centar Cair Round: 16
Head to Head
| Serbia Liga | 2021/11/12 18:00 | Spartak Subotica v Nis | L | 3-0 |
| Serbia Liga | 2021/02/06 14:00 | Nis v Spartak Subotica | W | 3-2 |
| Serbia Liga | 2020/10/16 17:00 | Spartak Subotica v Nis | L | 3-1 |
| Serbia Liga | 2020/02/22 16:00 | Nis v Spartak Subotica | W | 3-0 |
| Serbia Liga | 2020/02/10 16:00 | Nis v Spartak Subotica | W | 3-1 |
| Serbia Cup | 2019/12/03 18:00 | Spartak Subotica v Nis | L | 3-1 |
| Serbia Cup | 2019/11/20 16:00 | Nis v Spartak Subotica | W | 3-0 |
| Serbia Liga | 2019/11/15 18:00 | Spartak Subotica v Nis | W | 2-3 |
Home History
| Serbia Liga | 2022/02/04 17:00 | Partizan Beograd v Nis | L | 3-0 |
| Serbia Liga | 2022/01/29 16:00 | Nis v Vojvodina Novi Sad | L | 1-3 |
| Serbia Liga | 2021/12/25 18:00 | Metalac Takovo v Nis | L | 3-2 |
| Serbia Liga | 2021/12/18 15:00 | Nis v Ribnica | L | 1-3 |
| Serbia Liga | 2021/12/11 16:00 | Radnicki Kragujevac v Nis | L | 3-0 |
| Challenge Cup | 2021/12/08 17:00 | Nis v Sporting CP | L | 1-3 |
| Serbia Liga | 2021/12/05 15:00 | Nis v Spartak Ljig | L | 1-3 |
| Challenge Cup | 2021/11/30 20:00 | Sporting CP v Nis | L | 3-1 |
Away History
| Serbia Liga | 2022/02/08 18:00 | Spartak Subotica v Partizan Beograd | W | 3-1 |
| Serbia Liga | 2022/02/04 18:00 | Spartak Subotica v Crvena Zvezda | W | 3-0 |
| Serbia Liga | 2021/12/22 16:30 | Vojvodina Novi Sad v Spartak Subotica | L | 3-0 |
| Serbia Liga | 2021/12/17 18:00 | Spartak Subotica v Metalac Takovo | W | 3-1 |
| Serbia Liga | 2021/12/12 18:00 | Ribnica v Spartak Subotica | L | 3-0 |
| Serbia Liga | 2021/12/03 18:00 | Spartak Subotica v Radnicki Kragujevac | L | 0-3 |
| Serbia Liga | 2021/11/26 18:00 | Spartak Subotica v Spartak Ljig | W | 3-1 |
| Serbia Liga | 2021/11/20 18:00 | Mladi Radnik v Spartak Subotica | W | 1-3 |