[4] Penarol 3-0 Montevideo Wanderers [1] 2021-10-04 00:00
Stadium: Estadio Campeon del Siglo Round: 4
Referee: Andres Matonte Home Manager: Mauricio Larriera Away Manager: Daniel Carreno
Head to Head
| Uruguay Apertura | 2021/06/06 23:15 | Montevideo Wanderers v Penarol | D | 0-0 |
| Uruguay Clausura | 2021/02/21 00:45 | Montevideo Wanderers v Penarol | W | 0-1 |
| Uruguay Apertura | 2020/08/30 23:15 | Penarol v Montevideo Wanderers | L | 0-2 |
| Uruguay Clausura | 2019/10/10 23:00 | Penarol v Montevideo Wanderers | W | 1-0 |
| Uruguay Apertura | 2019/03/17 22:30 | Montevideo Wanderers v Penarol | L | 2-0 |
| Uruguay Clausura | 2018/08/04 19:00 | Penarol v Montevideo Wanderers | W | 3-0 |
| Uruguay Apertura | 2018/02/17 20:00 | Montevideo Wanderers v Penarol | D | 1-1 |
| Uruguay Clausura | 2017/09/09 22:00 | Penarol v Montevideo Wanderers | W | 2-0 |
Home History
| Copa Sudamericana | 2021/10/01 00:30 | Athletico Paranaense v Penarol | L | 2-0 |
| Uruguay Clausura | 2021/09/26 18:30 | Boston River v Penarol | W | 2-5 |
| Copa Sudamericana | 2021/09/24 00:30 | Penarol v Athletico Paranaense | L | 1-2 |
| Uruguay Clausura | 2021/09/17 23:00 | Penarol v Atletico Fenix Montevideo | D | 0-0 |
| Uruguay Clausura | 2021/09/12 18:30 | Plaza Colonia v Penarol | W | 1-2 |
| Uruguay Apertura | 2021/08/22 18:00 | IA Sud America v Penarol | D | 1-1 |
| Copa Sudamericana | 2021/08/18 22:15 | Penarol v Sporting Cristal | W | 1-0 |
| Uruguay Apertura | 2021/08/14 22:00 | Penarol v Club Atletico Progreso | W | 1-0 |
Away History
| Uruguay Clausura | 2021/09/26 20:45 | Montevideo Wanderers v Rentistas | W | 2-1 |
| Uruguay Clausura | 2021/09/20 18:30 | Deportivo Maldonado v Montevideo Wanderers | W | 1-3 |
| Uruguay Clausura | 2021/09/12 15:30 | Boston River v Montevideo Wanderers | W | 1-3 |
| Uruguay Apertura | 2021/08/20 18:00 | Atletico Fenix Montevideo v Montevideo Wanderers | L | 2-1 |
| Uruguay Apertura | 2021/08/15 23:30 | Montevideo Wanderers v Plaza Colonia | L | 0-2 |
| Uruguay Apertura | 2021/08/09 15:45 | IA Sud America v Montevideo Wanderers | L | 1-0 |
| Uruguay Apertura | 2021/07/31 20:15 | Montevideo Wanderers v Club Atletico Progreso | W | 2-0 |
| Uruguay Apertura | 2021/07/17 20:15 | Cerro Largo v Montevideo Wanderers | L | 2-0 |