Head to Head
| Ghana Premier League | 2021/04/24 15:00 | Asante Kotoko v Medeama SC | L | 1-2 |
| Ghana Premier League | 2020/12/27 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2020/01/15 15:00 | Medeama SC v Asante Kotoko | L | 1-0 |
| Ghana Premier League | 2018/03/28 15:00 | Medeama SC v Asante Kotoko | L | 1-0 |
| Ghana FA Cup | 2017/10/02 15:00 | Asante Kotoko v Medeama SC | W | 1-0 |
| Ghana FA Cup | 2017/10/01 18:00 | Asante Kotoko v Medeama SC | D | 0-0 |
| Ghana Premier League | 2017/07/09 15:00 | Asante Kotoko v Medeama SC | W | 3-1 |
| Ghana Premier League | 2017/04/05 15:00 | Medeama SC v Asante Kotoko | L | 2-1 |
Home History
| Ghana Premier League | 2022/01/15 15:00 | Berekum Chelsea v Asante Kotoko | D | 0-0 |
| Ghana Premier League | 2022/01/09 15:00 | Asante Kotoko v Ashanti Gold | W | 3-1 |
| Ghana Premier League | 2022/01/01 15:00 | Aduana Stars v Asante Kotoko | W | 0-2 |
| Ghana FA Cup | 2021/12/29 15:00 | King Faisal v Asante Kotoko | L | 1-0 |
| Ghana Premier League | 2021/12/26 15:00 | Asante Kotoko v WAFA | W | 1-0 |
| Ghana Premier League | 2021/12/19 15:00 | Legon Cities FC v Asante Kotoko | W | 1-2 |
| Ghana Premier League | 2021/12/15 18:00 | Asante Kotoko v Real Tamale United | D | 1-1 |
| Ghana Premier League | 2021/12/05 15:00 | Asante Kotoko v King Faisal | L | 2-3 |
Away History
| Ghana Premier League | 2022/01/16 15:00 | Medeama SC v Great Olympics | D | 0-0 |
| Ghana Premier League | 2022/01/12 15:00 | Medeama SC v Hearts of Oak | W | 1-0 |
| Ghana Premier League | 2022/01/07 15:00 | Medeama SC v Berekum Chelsea | D | 1-1 |
| Ghana Premier League | 2022/01/03 15:00 | Ashanti Gold v Medeama SC | W | 0-1 |
| Ghana FA Cup | 2021/12/29 15:00 | Karela United FC v Medeama SC | D | 2-2 |
| Ghana Premier League | 2021/12/26 15:00 | Medeama SC v Aduana Stars | W | 1-0 |
| Ghana Premier League | 2021/12/19 15:00 | WAFA v Medeama SC | L | 1-0 |
| Ghana Premier League | 2021/12/15 15:00 | Medeama SC v Legon Cities FC | W | 1-0 |