| Panama Liga Prom | 2021/08/07 22:00 | Aguilas de la U v San Francisco Reserves | D | 2-2 |
| Panama Liga Prom | 2021/04/17 22:00 | Aguilas de la U v San Francisco Reserves | D | 1-1 |
| Panama Liga Prom | 2021/10/17 00:00 | San Francisco Reserves v Union Cocle | W | 3-0 |
| Panama Liga Prom | 2021/10/08 23:00 | Herrera FC Reserves v San Francisco Reserves | D | 2-2 |
| Panama Liga Prom | 2021/10/03 22:00 | Atletico Chiriqui B v San Francisco Reserves | L | 2-1 |
| Panama Liga Prom | 2021/09/24 20:00 | CD Universitario Reserves v San Francisco Reserves | W | 2-4 |
| Panama Liga Prom | 2021/09/19 00:00 | San Francisco Reserves v Mario Mendez FC | L | 0-1 |
| Panama Liga Prom | 2021/09/10 21:00 | Veraguas CD Reserves v San Francisco Reserves | W | 0-1 |
| Panama Liga Prom | 2021/09/04 00:00 | SD Panama Oeste v San Francisco Reserves | L | 2-1 |
| Panama Liga Prom | 2021/08/28 22:00 | San Francisco Reserves v CA Independiente de la Chorrera Reserves | D | 0-0 |
| Panama Liga Prom | 2021/10/16 22:00 | Aguilas de la U v Veraguas CD Reserves | D | 1-1 |
| Panama Liga Prom | 2021/10/02 22:00 | Aguilas de la U v CD Universitario Reserves | W | 3-2 |
| Panama Liga Prom | 2021/09/26 22:00 | Aguilas de la U v Herrera FC Reserves | W | 2-0 |
| Panama Liga Prom | 2021/09/17 23:00 | Atletico Chiriqui B v Aguilas de la U | D | 0-0 |
| Panama Liga Prom | 2021/09/10 23:00 | Mario Mendez FC v Aguilas de la U | L | 1-0 |
| Panama Liga Prom | 2021/09/03 20:00 | Udelas FC v Aguilas de la U | L | 3-1 |
| Panama Liga Prom | 2021/08/29 22:00 | Aguilas de la U v SD Panama Oeste | W | 2-1 |
| Panama Liga Prom | 2021/08/20 23:00 | SD Atletico Nacional v Aguilas de la U | L | 3-2 |