Stadium: Theodore A. Wright Stadium Round: 1
| NCAAF | 2021/10/30 18:00 | Fort Valley State v Savannah State | W | 6-24 |
| NCAAF | 2021/10/23 18:00 | Albany State Golden Rams v Savannah State | L | 30-0 |
| NCAAF | 2021/10/16 19:00 | Savannah State v Clark Atlanta University | W | 49-14 |
| NCAAF | 2021/10/09 22:00 | Savannah State v Erskine Flying Fleet | W | 39-6 |
| NCAAF | 2021/10/02 17:00 | Kentucky Thorobreds v Savannah State | W | 17-21 |
| NCAAF | 2021/09/25 22:00 | Savannah State v Morehouse College Maroon Tigers | W | 29-10 |
| NCAAF | 2021/09/18 22:00 | Savannah State v Benedict College | W | 41-34 |
| NCAAF | 2021/09/11 22:00 | Savannah State v Livingstone C. BB | W | 50-6 |
| NCAAF | 2021/10/30 22:00 | Edward Waters Tigers v Miles Golden Bears | L | 9-16 |
| NCAAF | 2021/10/23 18:00 | Edward Waters Tigers v Central State | W | 56-19 |
| NCAAF | 2021/10/16 17:00 | Edward Waters Tigers v Kentucky Thorobreds | L | 36-76 |
| NCAAF | 2021/10/09 18:00 | Albany State Golden Rams v Edward Waters Tigers | L | 30-0 |
| NCAAF | 2021/10/02 18:00 | Morehouse College Maroon Tigers v Edward Waters Tigers | W | 13-37 |
| NCAAF | 2021/09/25 22:00 | Edward Waters Tigers v Lane College Dragons | L | 35-45 |
| NCAAF | 2021/09/09 23:30 | Benedict College v Edward Waters Tigers | L | 44-3 |
| NCAAF | 2021/02/21 19:00 | Jackson State v Edward Waters Tigers | L | 53-0 |