[11] SJ Sharks 3-2 BUF Sabres [14] 2022-01-07 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Bob Boughner
Head to Head
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | W | 3-5 |
| NHL | 2019/10/22 23:00 | SJ Sharks v BUF Sabres | L | 3-4 |
| NHL | 2019/10/20 02:30 | BUF Sabres v SJ Sharks | L | 4-3 |
| NHL | 2018/11/28 00:00 | SJ Sharks v BUF Sabres | L | 2-3 |
| NHL | 2018/10/19 02:30 | BUF Sabres v SJ Sharks | W | 1-5 |
| NHL | 2017/10/28 17:00 | SJ Sharks v BUF Sabres | W | 3-2 |
| NHL | 2017/10/13 02:30 | BUF Sabres v SJ Sharks | W | 2-3 |
| NHL | 2017/03/15 02:30 | BUF Sabres v SJ Sharks | W | 1-4 |
Home History
| NHL | 2022/01/05 00:30 | SJ Sharks v DET Red Wings | L | 2-6 |
| NHL | 2022/01/02 18:00 | SJ Sharks v PIT Penguins | L | 5-8 |
| NHL | 2021/12/31 03:30 | PHI Flyers v SJ Sharks | W | 2-3 |
| NHL | 2021/12/29 03:30 | ARZ Coyotes v SJ Sharks | W | 7-8 |
| NHL | 2021/12/17 03:30 | VAN Canucks v SJ Sharks | L | 5-2 |
| NHL | 2021/12/15 03:30 | SEA Kraken v SJ Sharks | L | 3-1 |
| NHL | 2021/12/12 03:30 | DAL Stars v SJ Sharks | W | 1-2 |
| NHL | 2021/12/10 03:30 | MIN Wild v SJ Sharks | L | 5-2 |
Away History
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | L | 1-4 |
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | L | 2-3 |
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
| NHL | 2021/12/15 01:00 | BUF Sabres v WIN Jets | W | 4-2 |
| NHL | 2021/12/12 00:00 | WAS Capitals v BUF Sabres | L | 3-2 |
| NHL | 2021/12/11 00:00 | NY Rangers v BUF Sabres | L | 2-1 |