[2] TB Lightning 6-1 BUF Sabres [6] 2022-01-12 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Jon Cooper
Head to Head
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | L | 1-5 |
| NHL | 2020/01/01 00:00 | TB Lightning v BUF Sabres | W | 6-4 |
| NHL | 2019/11/26 00:00 | BUF Sabres v TB Lightning | W | 2-5 |
| NHL | 2019/11/09 18:00 | BUF Sabres v TB Lightning | W | 3-5 |
| NHL | 2019/11/08 19:00 | TB Lightning v BUF Sabres | W | 3-2 |
| NHL | 2019/02/22 00:30 | BUF Sabres v TB Lightning | W | 1-2 |
| NHL | 2019/01/13 00:00 | TB Lightning v BUF Sabres | W | 5-3 |
| NHL | 2018/11/30 00:30 | BUF Sabres v TB Lightning | W | 4-5 |
Home History
| NHL | 2022/01/09 00:00 | BOS Bruins v TB Lightning | L | 5-2 |
| NHL | 2022/01/07 00:00 | CAL Flames v TB Lightning | W | 1-4 |
| NHL | 2022/01/05 00:00 | TB Lightning v CLB Blue Jackets | W | 7-2 |
| NHL | 2022/01/02 17:30 | TB Lightning v NY Rangers | L | 0-4 |
| NHL | 2022/01/01 00:00 | NY Rangers v TB Lightning | L | 4-3 |
| NHL | 2021/12/31 00:00 | TB Lightning v FLA Panthers | L | 3-9 |
| NHL | 2021/12/29 00:00 | MON Canadiens v TB Lightning | W | 4-5 |
| NHL | 2021/12/22 03:00 | TB Lightning v VGS Golden Knights | W | 4-3 |
Away History
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | L | 1-4 |
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | L | 2-3 |
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
| NHL | 2021/12/15 01:00 | BUF Sabres v WIN Jets | W | 4-2 |
| NHL | 2021/12/12 00:00 | WAS Capitals v BUF Sabres | L | 3-2 |