[6] BUF Sabres 0-4 DET Red Wings [5] 2022-01-16 00:00
Stadium: Little Caesars Arena
Home Manager: Jeff Blashill Away Manager: Don Granato
Head to Head
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | L | 2-3 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL | 2020/02/12 00:00 | DET Red Wings v BUF Sabres | W | 2-3 |
| NHL | 2020/02/07 00:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL | 2020/01/12 22:00 | BUF Sabres v DET Red Wings | W | 5-1 |
| NHL | 2019/10/25 23:30 | BUF Sabres v DET Red Wings | W | 2-0 |
Home History
| NHL | 2022/01/14 01:00 | BUF Sabres v NAS Predators | W | 4-1 |
| NHL | 2022/01/12 00:00 | TB Lightning v BUF Sabres | L | 6-1 |
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | L | 1-4 |
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | L | 2-3 |
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
Away History
| NHL | 2022/01/14 00:30 | WIN Jets v DET Red Wings | L | 3-0 |
| NHL | 2022/01/12 03:30 | DET Red Wings v SJ Sharks | L | 2-3 |
| NHL | 2022/01/10 01:00 | DET Red Wings v ANA Ducks | L | 3-4 |
| NHL | 2022/01/09 03:30 | DET Red Wings v LA Kings | L | 0-4 |
| NHL | 2022/01/05 00:30 | SJ Sharks v DET Red Wings | W | 2-6 |
| NHL | 2022/01/02 18:00 | BOS Bruins v DET Red Wings | L | 5-1 |
| NHL | 2022/01/01 00:30 | WAS Capitals v DET Red Wings | L | 3-1 |
| NHL | 2021/12/19 01:00 | NJ Devils v DET Red Wings | W | 2-5 |