[7] South Carolina Women 55-46 Duke Women [17] 2021-12-16 00:00
Stadium: Cameron Indoor Stadium
Home Manager: Kara Lawson Away Manager: Dawn Staley
Head to Head
| WNCAAB | 2019/12/20 00:00 | South Carolina Women v Duke Women | W | 89-46 |
| WNCAAB | 2017/12/03 17:00 | Duke Women v South Carolina Women | W | 52-72 |
Home History
| WNCAAB | 2021/12/12 20:00 | Maryland Women v South Carolina Women | W | 59-66 |
| WNCAAB | 2021/12/04 00:00 | Kansas State Women v South Carolina Women | W | 44-65 |
| WNCAAB | 2021/11/30 00:00 | North Carolina A&T Women v South Carolina Women | W | 42-79 |
| WNCAAB | 2021/11/26 20:00 | Elon Women v South Carolina Women | W | 38-79 |
| WNCAAB | 2021/11/22 17:00 | South Carolina Women v Connecticut Women | W | 73-57 |
| WNCAAB | 2021/11/21 19:30 | Oregon Women v South Carolina Women | W | 63-80 |
| WNCAAB | 2021/11/21 00:30 | Buffalo Women v South Carolina Women | W | 60-88 |
| WNCAAB | 2021/11/18 00:00 | Clemson Women v South Carolina Women | W | 45-76 |
Away History
| WNCAAB | 2021/12/05 18:00 | Duke Women v Pennsylvania Women | W | 77-55 |
| WNCAAB | 2021/12/03 02:00 | Iowa Women v Duke Women | W | 64-79 |
| WNCAAB | 2021/11/28 19:00 | Troy Women v Duke Women | W | 75-91 |
| WNCAAB | 2021/11/25 00:00 | Appalachian State Women v Duke Women | W | 65-73 |
| WNCAAB | 2021/11/21 19:00 | Alabama Women v Duke Women | W | 71-74 |
| WNCAAB | 2021/11/14 19:00 | UNC Wilmington Women v Duke Women | W | 45-87 |
| WNCAAB | 2021/11/13 00:00 | Duke Women v Dayton Women | W | 70-56 |
| WNCAAB | 2021/11/10 00:00 | Winthrop Women v Duke Women | W | 39-95 |