Stadium: TD Arena
Home Manager: Robin Harmony Away Manager: Darrick Gibbs
| WNCAAB | 2021/11/24 18:00 | North Florida Women v Clemson Women | L | 72-84 |
| WNCAAB | 2021/11/21 14:30 | Florida Atlantic Women v North Florida Women | W | 79-85 |
| WNCAAB | 2021/11/19 00:00 | North Florida Women v Webber International Women | W | 83-59 |
| WNCAAB | 2021/11/13 19:00 | North Florida Women v Trinity Baptist Women | W | 126-31 |
| WNCAAB | 2021/11/12 00:00 | North Florida Women v Warner (FL) Women | W | 92-40 |
| WNCAAB | 2021/11/10 00:00 | North Florida Women v Florida State Women | L | 50-78 |
| WNCAAB | 2021/03/13 00:00 | North Florida Women v Liberty Women | L | 52-65 |
| WNCAAB | 2021/03/12 00:00 | North Alabama Women v North Florida Women | W | 74-86 |
| WNCAAB | 2021/11/24 00:00 | Tarleton State Women v Charleston Women | L | 69-59 |
| WNCAAB | 2021/11/19 23:00 | Charleston Women v Norfolk State Women | W | 66-62 |
| WNCAAB | 2021/11/12 16:00 | Charleston Women v Pfeiffer Women | W | 113-52 |
| WNCAAB | 2021/11/10 00:30 | Charleston Women v Wofford Women | W | 80-48 |
| WNCAAB | 2021/03/10 19:30 | UNC Wilmington Women v Charleston Women | L | 60-47 |
| WNCAAB | 2021/02/28 18:00 | Charleston Women v UNC Wilmington Women | L | 54-61 |
| WNCAAB | 2021/02/27 00:00 | Charleston Women v UNC Wilmington Women | L | 66-68 |
| WNCAAB | 2021/02/07 18:00 | Towson Women v Charleston Women | L | 84-63 |