Stadium: Ellis T. Johnson Arena
Home Manager: Cayla Petree Away Manager: Samantha Quigley Smith
| WNCAAB | 2021/01/19 23:00 | Morehead State Women v SIU Edwardsville Women | L | 53-47 |
| WNCAAB | 2021/01/16 18:30 | SIU Edwardsville Women v Morehead State Women | L | 53-63 |
| WNCAAB | 2020/02/06 23:30 | Morehead State Women v SIU Edwardsville Women | L | 63-55 |
| WNCAAB | 2020/01/09 22:00 | Morehead State Women v SIU Edwardsville Women | L | 75-69 |
| WNCAAB | 2019/01/31 17:00 | SIU Edwardsville Women v Morehead State Women | L | 67-73 |
| WNCAAB | 2018/01/06 19:00 | Morehead State Women v SIU Edwardsville Women | W | 51-66 |
| WNCAAB | 2022/01/20 22:00 | SIU Edwardsville Women v Tennessee Tech Women | L | 60-75 |
| WNCAAB | 2022/01/18 00:00 | SIU Edwardsville Women v Austin Peay Women | L | 55-76 |
| WNCAAB | 2022/01/15 21:30 | SE Missouri State Women v SIU Edwardsville Women | W | 66-73 |
| WNCAAB | 2022/01/01 19:00 | SIU Edwardsville Women v Tennessee Martin Women | W | 62-58 |
| WNCAAB | 2021/12/30 23:30 | Belmont Women v SIU Edwardsville Women | L | 87-49 |
| WNCAAB | 2021/12/22 23:30 | Arkansas State Women v SIU Edwardsville Women | L | 74-71 |
| WNCAAB | 2021/12/19 21:30 | Toledo Women v SIU Edwardsville Women | L | 66-57 |
| WNCAAB | 2021/12/11 19:00 | Illinois State Women v SIU Edwardsville Women | L | 80-71 |
| WNCAAB | 2022/01/20 21:00 | Belmont Women v Morehead State Women | L | 103-50 |
| WNCAAB | 2022/01/08 19:30 | Morehead State Women v Austin Peay Women | L | 49-66 |
| WNCAAB | 2022/01/06 19:00 | Morehead State Women v Tennessee Tech Women | L | 48-78 |
| WNCAAB | 2022/01/01 19:00 | Tennessee State Women v Morehead State Women | L | 58-34 |
| WNCAAB | 2021/12/29 22:00 | Eastern Illinois Women v Morehead State Women | L | 91-64 |
| WNCAAB | 2021/12/19 18:00 | Valparaiso Women v Morehead State Women | L | 65-57 |
| WNCAAB | 2021/12/18 19:00 | Morehead State Women v USC Upstate Women | L | 52-66 |
| WNCAAB | 2021/12/15 22:00 | Morehead State Women v Eastern Kentucky Women | L | 43-66 |