Stadium: Sam M. Vadalabene Center
Home Manager: Samantha Quigley Smith Away Manager: Destinee Rogers
| WNCAAB | 2021/12/19 22:00 | Arkansas State Women v Hendrix Women | W | 98-48 |
| WNCAAB | 2021/12/15 01:00 | Mississippi Valley State Women v Arkansas State Women | W | 47-81 |
| WNCAAB | 2021/12/09 01:00 | Arkansas State Women v Utah State Women | L | 65-66 |
| WNCAAB | 2021/12/03 01:00 | Northwestern State Women v Arkansas State Women | L | 80-76 |
| WNCAAB | 2021/11/28 17:00 | Arkansas State Women v Abilene Christian Women | L | 69-81 |
| WNCAAB | 2021/11/27 20:00 | Arkansas State Women v Oral Roberts Women | L | 62-81 |
| WNCAAB | 2021/11/24 01:00 | Arkansas State Women v University of The Ozarks Women | W | 95-49 |
| WNCAAB | 2021/11/22 23:00 | Arkansas State Women v SE Missouri State Women | W | 73-65 |
| WNCAAB | 2021/12/19 21:30 | Toledo Women v SIU Edwardsville Women | L | 66-57 |
| WNCAAB | 2021/12/11 19:00 | Illinois State Women v SIU Edwardsville Women | L | 80-71 |
| WNCAAB | 2021/12/10 01:00 | St Louis Women v SIU Edwardsville Women | W | 57-63 |
| WNCAAB | 2021/12/08 00:00 | Western Illinois Women v SIU Edwardsville Women | L | 96-93 |
| WNCAAB | 2021/12/03 01:00 | SIU Edwardsville Women v Missouri Women | L | 46-79 |
| WNCAAB | 2021/11/28 20:00 | Purdue Fort Wayne Women v SIU Edwardsville Women | W | 56-68 |
| WNCAAB | 2021/11/23 17:00 | SIU Edwardsville Women v Butler Women | W | 87-74 |
| WNCAAB | 2021/11/19 01:00 | SIU Edwardsville Women v Illinois Women | W | 71-62 |