Stadium: W.S. Hanner Fieldhouse
Home Manager: Rick Pietri Away Manager: Chad Killinger
| WNCAAB | 2021/11/24 18:00 | Indiana State Women v Western Kentucky Women | L | 65-83 |
| WNCAAB | 2021/11/17 23:00 | Eastern Illinois Women v Indiana State Women | L | 64-55 |
| WNCAAB | 2021/11/14 19:00 | Indiana State Women v St Louis Women | L | 58-65 |
| WNCAAB | 2021/11/09 23:00 | Indiana State Women v Stephens Women | W | 88-33 |
| WNCAAB | 2021/03/11 22:30 | Indiana State Women v Southern Illinois Women | L | 89-90 |
| WNCAAB | 2021/03/06 22:00 | Bradley Women v Indiana State Women | L | 80-58 |
| WNCAAB | 2021/03/06 00:00 | Bradley Women v Indiana State Women | L | 86-52 |
| WNCAAB | 2021/02/24 23:00 | Evansville Women v Indiana State Women | W | 69-85 |
| WNCAAB | 2021/11/21 20:00 | Jacksonville State Women v Vanderbilt Women | L | 61-71 |
| WNCAAB | 2021/11/18 00:00 | Jacksonville State Women v Samford Women | W | 56-53 |
| WNCAAB | 2021/11/14 18:00 | Jacksonville State Women v Davidson Women | L | 58-69 |
| WNCAAB | 2021/11/09 16:30 | Jacksonville State Women v Auburn Montgomery Women | W | 89-39 |
| WNCAAB | 2021/03/04 19:00 | Tennessee Tech Women v Jacksonville State Women | L | 79-64 |
| WNCAAB | 2021/02/27 19:00 | Jacksonville State Women v Austin Peay Women | W | 60-44 |
| WNCAAB | 2021/02/25 22:30 | Jacksonville State Women v Murray State Women | L | 75-78 |
| WNCAAB | 2021/02/22 19:00 | Jacksonville State Women v SIU Edwardsville Women | W | 61-47 |