Stadium: Sam M. Vadalabene Center
Home Manager: Samantha Quigley Smith Away Manager: Maria Marchesano
| WNCAAB | 2020/11/25 18:00 | Purdue Fort Wayne Women v SIU Edwardsville Women | L | 50-66 |
| WNCAAB | 2019/12/04 23:30 | SIU Edwardsville Women v Purdue Fort Wayne Women | L | 57-53 |
| WNCAAB | 2018/11/24 19:00 | Purdue Fort Wayne Women v SIU Edwardsville Women | L | 49-57 |
| WNCAAB | 2021/11/24 19:00 | Evansville Women v Purdue Fort Wayne Women | L | 84-71 |
| WNCAAB | 2021/11/19 00:00 | UIC Women v Purdue Fort Wayne Women | W | 63-69 |
| WNCAAB | 2021/11/09 22:00 | Purdue Fort Wayne Women v Manchester Spartans Women | W | 102-35 |
| WNCAAB | 2021/02/25 22:00 | Purdue Fort Wayne Women v Youngstown State Women | L | 59-62 |
| WNCAAB | 2021/02/20 17:00 | Robert Morris Women v Purdue Fort Wayne Women | L | 77-63 |
| WNCAAB | 2021/02/19 19:00 | Robert Morris Women v Purdue Fort Wayne Women | W | 67-71 |
| WNCAAB | 2021/02/13 18:00 | Cleveland State Women v Purdue Fort Wayne Women | L | 71-61 |
| WNCAAB | 2021/02/12 18:00 | Purdue Fort Wayne Women v Cleveland State Women | L | 45-68 |
| WNCAAB | 2021/11/23 17:00 | SIU Edwardsville Women v Butler Women | W | 87-74 |
| WNCAAB | 2021/11/19 01:00 | SIU Edwardsville Women v Illinois Women | W | 71-62 |
| WNCAAB | 2021/11/14 20:00 | SIU Edwardsville Women v Memphis Women | L | 58-89 |
| WNCAAB | 2021/11/11 01:00 | SIU Edwardsville Women v Kansas Women | L | 62-98 |
| WNCAAB | 2021/02/27 19:00 | SIU Edwardsville Women v SE Missouri State Women | L | 52-63 |
| WNCAAB | 2021/02/25 19:00 | Tennessee Martin Women v SIU Edwardsville Women | L | 68-52 |
| WNCAAB | 2021/02/22 19:00 | Jacksonville State Women v SIU Edwardsville Women | L | 61-47 |
| WNCAAB | 2021/02/20 22:30 | Murray State Women v SIU Edwardsville Women | L | 68-60 |