Stadium: Hilliard Gates Sports Center
Home Manager: Maria Marchesano Away Manager: Chad Killinger
| WNCAAB | 2021/12/14 23:00 | UIC Women v Indiana State Women | W | 50-76 |
| WNCAAB | 2021/12/11 19:00 | Indiana State Women v Nebraska Women | L | 50-78 |
| WNCAAB | 2021/12/04 23:00 | Western Michigan Women v Indiana State Women | L | 68-67 |
| WNCAAB | 2021/12/02 00:00 | Chicago State Women v Indiana State Women | W | 58-59 |
| WNCAAB | 2021/11/27 20:30 | Indiana State Women v Georgia Southern Women | W | 71-67 |
| WNCAAB | 2021/11/26 20:30 | Indiana State Women v Jacksonville State Women | L | 57-67 |
| WNCAAB | 2021/11/24 18:00 | Indiana State Women v Western Kentucky Women | L | 65-83 |
| WNCAAB | 2021/11/17 23:00 | Eastern Illinois Women v Indiana State Women | L | 64-55 |
| WNCAAB | 2021/12/12 19:00 | Purdue Fort Wayne Women v Notre Dame Women | L | 41-78 |
| WNCAAB | 2021/12/10 00:30 | SE Missouri State Women v Purdue Fort Wayne Women | L | 68-51 |
| WNCAAB | 2021/12/05 19:00 | Purdue Fort Wayne Women v Northern Kentucky Women | L | 60-69 |
| WNCAAB | 2021/12/02 23:30 | Ball State Women v Purdue Fort Wayne Women | L | 86-58 |
| WNCAAB | 2021/11/28 20:00 | Purdue Fort Wayne Women v SIU Edwardsville Women | L | 56-68 |
| WNCAAB | 2021/11/24 19:00 | Evansville Women v Purdue Fort Wayne Women | L | 84-71 |
| WNCAAB | 2021/11/19 00:00 | UIC Women v Purdue Fort Wayne Women | W | 63-69 |
| WNCAAB | 2021/11/09 22:00 | Purdue Fort Wayne Women v Manchester Spartans Women | W | 102-35 |