Stadium: The Buc Dome
Home Manager: Clarisse Garcia Away Manager: Vanessa Blair-Lewis
| WNCAAB | 2021/11/14 17:00 | Virginia Tech Women v George Mason Women | L | 81-52 |
| WNCAAB | 2021/11/12 16:30 | George Mason Women v Loyola Maryland Women | W | 53-51 |
| WNCAAB | 2021/11/10 00:00 | George Mason Women v Florida Intl Women | W | 12-6 |
| WNCAAB | 2021/03/10 21:00 | George Mason Women v George Washington Women | L | 56-62 |
| WNCAAB | 2021/02/28 19:00 | George Mason Women v George Washington Women | L | 39-68 |
| WNCAAB | 2021/02/21 00:00 | George Mason Women v Davidson Women | L | 42-68 |
| WNCAAB | 2021/02/14 19:00 | George Mason Women v Duquesne Women | L | 49-55 |
| WNCAAB | 2021/02/12 23:00 | George Mason Women v St Bonaventure Women | L | 62-72 |
| WNCAAB | 2021/11/09 23:00 | Charleston Southern Women v Alabama Women | L | 32-109 |
| WNCAAB | 2021/03/06 19:00 | USC Upstate Women v Charleston Southern Women | L | 72-64 |
| WNCAAB | 2021/02/21 18:00 | Charleston Southern Women v Radford Women | L | 67-76 |
| WNCAAB | 2021/02/20 19:00 | Radford Women v Charleston Southern Women | L | 74-73 |
| WNCAAB | 2021/02/13 20:00 | Longwood Women v Charleston Southern Women | L | 76-51 |
| WNCAAB | 2021/02/13 00:00 | Longwood Women v Charleston Southern Women | L | 94-48 |
| WNCAAB | 2021/02/06 23:00 | Charleston Southern Women v High Point Women | L | 54-71 |
| WNCAAB | 2021/02/06 00:00 | Charleston Southern Women v High Point Women | L | 65-88 |