Stadium: Kaplan Arena
Home Manager: Ed Swanson Away Manager: Vanessa Blair-Lewis
| WNCAAB | 2021/11/16 23:00 | George Mason Women v Charleston Southern Women | W | 64-55 |
| WNCAAB | 2021/11/14 17:00 | Virginia Tech Women v George Mason Women | L | 81-52 |
| WNCAAB | 2021/11/12 16:30 | George Mason Women v Loyola Maryland Women | W | 53-51 |
| WNCAAB | 2021/11/10 00:00 | George Mason Women v Florida Intl Women | W | 12-6 |
| WNCAAB | 2021/03/10 21:00 | George Mason Women v George Washington Women | L | 56-62 |
| WNCAAB | 2021/02/28 19:00 | George Mason Women v George Washington Women | L | 39-68 |
| WNCAAB | 2021/02/21 00:00 | George Mason Women v Davidson Women | L | 42-68 |
| WNCAAB | 2021/02/14 19:00 | George Mason Women v Duquesne Women | L | 49-55 |
| WNCAAB | 2021/11/17 00:00 | William & Mary Women v Navy Women | L | 54-66 |
| WNCAAB | 2021/11/14 19:00 | William & Mary Women v Randolph Women | W | 83-31 |
| WNCAAB | 2021/11/12 00:00 | Coppin State Women v William & Mary Women | L | 73-56 |
| WNCAAB | 2021/01/24 18:00 | Charleston Women v William & Mary Women | L | 69-66 |
| WNCAAB | 2021/01/23 18:00 | Charleston Women v William & Mary Women | W | 44-57 |
| WNCAAB | 2021/01/17 19:00 | William & Mary Women v Drexel Women | W | 69-53 |
| WNCAAB | 2021/01/16 19:00 | William & Mary Women v Drexel Women | L | 58-64 |
| WNCAAB | 2021/01/10 18:00 | Delaware Women v William & Mary Women | L | 77-64 |