[39] Central Florida 28-55 SMU [21] 2021-11-13 17:00
Stadium: Gerald J. Ford Stadium Round: 1
Home Manager: Sonny Dykes Away Manager: Gus Malzahn
Head to Head
| NCAAF | 2018/10/06 23:00 | SMU v Central Florida | W | 20-48 |
| NCAAF | 2017/11/04 23:15 | Central Florida v SMU | W | 31-24 |
| NCAAF | 2014/11/22 17:00 | Central Florida v SMU | W | 53-7 |
| NCAAF | 2012/11/03 12:00 | Central Florida v SMU | W | 42-17 |
| NCAAF | 2011/10/15 12:00 | SMU v Central Florida | L | 38-17 |
| NCAAF | 2010/12/04 12:00 | Central Florida v SMU | W | 17-7 |
| NCAAF | 2008/10/04 12:00 | Central Florida v SMU | W | 31-17 |
| NCAAF | 2007/11/17 12:00 | SMU v Central Florida | W | 20-49 |
Home History
| NCAAF | 2021/11/06 20:00 | Tulane v Central Florida | W | 10-14 |
| NCAAF | 2021/10/30 16:00 | Central Florida v Temple | W | 49-7 |
| NCAAF | 2021/10/22 23:00 | Memphis v Central Florida | W | 7-24 |
| NCAAF | 2021/10/16 16:00 | Central Florida v Cincinnati | L | 21-56 |
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | W | 16-20 |
| NCAAF | 2021/10/02 19:30 | Central Florida v Navy | L | 30-34 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | L | 35-42 |
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | W | 14-63 |
Away History
| NCAAF | 2021/11/06 16:00 | SMU v Memphis | L | 25-28 |
| NCAAF | 2021/10/30 23:00 | SMU v Houston | L | 37-44 |
| NCAAF | 2021/10/21 23:30 | Tulane v SMU | W | 26-55 |
| NCAAF | 2021/10/09 19:30 | SMU v Navy | W | 31-24 |
| NCAAF | 2021/10/02 20:00 | South Florida v SMU | W | 17-41 |
| NCAAF | 2021/09/25 16:00 | SMU v TCU | W | 42-34 |
| NCAAF | 2021/09/18 19:30 | SMU v Louisiana Tech | W | 39-37 |
| NCAAF | 2021/09/11 23:00 | North Texas v SMU | W | 12-35 |