Stadium: William H. Detrick Gymnasium
Home Manager: Patrick Sellers Away Manager: Brett Nelson
| NCAAB | 2021/11/27 22:00 | New Hampshire v Holy Cross | L | 70-55 |
| NCAAB | 2021/11/24 08:27 | Mount Saint Vincent v Holy Cross | W | 52-95 |
| NCAAB | 2021/11/21 17:00 | Bryant v Holy Cross | L | 78-62 |
| NCAAB | 2021/11/20 19:30 | Air Force v Holy Cross | L | 72-53 |
| NCAAB | 2021/11/16 00:00 | Holy Cross v Quinnipiac | L | 68-76 |
| NCAAB | 2021/11/13 00:00 | Holy Cross v Boston College | L | 55-85 |
| NCAAB | 2021/11/10 00:00 | Holy Cross v Regis (MA) | W | 98-51 |
| NCAAB | 2021/02/25 00:00 | Holy Cross v Boston U | W | 86-75 |
| NCAAB | 2021/11/28 18:00 | Fordham v Central Connecticut | L | 89-83 |
| NCAAB | 2021/11/24 00:00 | Central Connecticut v Maine | W | 64-56 |
| NCAAB | 2021/11/20 18:00 | Central Connecticut v Quinnipiac | L | 65-76 |
| NCAAB | 2021/11/17 22:00 | Central Connecticut v UMass Lowell | L | 53-77 |
| NCAAB | 2021/11/17 01:00 | Central Connecticut v NC State | L | 65-79 |
| NCAAB | 2021/11/14 21:00 | Central Connecticut v Brown | L | 57-75 |
| NCAAB | 2021/11/09 23:30 | Central Connecticut v Connecticut | L | 48-99 |
| NCAAB | 2021/02/26 21:00 | Wagner v Central Connecticut | W | 77-83 |