Stadium: Chartway Arena
Home Manager: Jeff Jones Away Manager: Pat Kelsey
| NCAAB | 2021/12/17 00:00 | Coll Of Charleston v Stetson | L | 59-67 |
| NCAAB | 2021/12/12 19:00 | Presbyterian v Coll Of Charleston | W | 76-78 |
| NCAAB | 2021/12/08 01:00 | Coll Of Charleston v Tulane | W | 86-72 |
| NCAAB | 2021/12/04 00:00 | Coll Of Charleston v Furman | L | 88-91 |
| NCAAB | 2021/12/01 00:30 | Tulane v Coll Of Charleston | W | 77-81 |
| NCAAB | 2021/11/27 21:00 | Coll Of Charleston v Chattanooga | W | 68-66 |
| NCAAB | 2021/11/23 01:00 | Coll Of Charleston v Oklahoma State | L | 66-96 |
| NCAAB | 2021/11/17 01:30 | North Carolina v Coll Of Charleston | L | 94-83 |
| NCAAB | 2021/12/19 21:00 | Old Dominion v Richmond | L | 61-67 |
| NCAAB | 2021/12/12 01:00 | VA Commonwealth v Old Dominion | L | 75-66 |
| NCAAB | 2021/12/08 00:00 | Old Dominion v William & Mary | W | 74-59 |
| NCAAB | 2021/12/05 00:00 | Old Dominion v George Mason | W | 60-50 |
| NCAAB | 2021/12/01 00:00 | Old Dominion v East Carolina | L | 62-63 |
| NCAAB | 2021/11/26 21:00 | Longwood v Old Dominion | W | 61-62 |
| NCAAB | 2021/11/21 17:30 | Old Dominion v Pennsylvania | L | 63-71 |
| NCAAB | 2021/11/20 00:30 | East Carolina v Old Dominion | L | 73-60 |