Stadium: Leavey Center
Home Manager: Herb Sendek Away Manager: Dan Engelstad
| NCAAB | 2021/12/04 18:00 | Mount St Marys v Loyola Maryland | L | 55-61 |
| NCAAB | 2021/12/01 00:00 | Howard v Mount St Marys | W | 70-72 |
| NCAAB | 2021/11/27 19:00 | Navy v Mount St Marys | L | 67-40 |
| NCAAB | 2021/11/23 00:00 | Mount St Marys v Ohio | L | 59-73 |
| NCAAB | 2021/11/20 00:00 | Mount St Marys v Robert Morris | W | 74-70 |
| NCAAB | 2021/11/17 00:00 | Mount St Marys v Kentucky | L | 55-80 |
| NCAAB | 2021/11/13 18:00 | Mount St Marys v St Josephs | L | 60-80 |
| NCAAB | 2021/11/12 00:00 | Mount St Marys v Washington University | W | 117-62 |
| NCAAB | 2021/12/04 22:00 | Louisiana Tech v Santa Clara | L | 78-75 |
| NCAAB | 2021/12/01 02:00 | Hawaii v Santa Clara | W | 58-70 |
| NCAAB | 2021/11/28 00:30 | UC Irvine v Santa Clara | L | 69-64 |
| NCAAB | 2021/11/25 06:00 | Fresno St v Santa Clara | L | 59-52 |
| NCAAB | 2021/11/23 03:30 | TCU v Santa Clara | W | 66-85 |
| NCAAB | 2021/11/20 02:00 | Cal Poly SLO v Santa Clara | W | 57-87 |
| NCAAB | 2021/11/17 02:00 | Nevada v Santa Clara | W | 74-96 |
| NCAAB | 2021/11/13 04:00 | Stanford v Santa Clara | W | 72-88 |