Stadium: Michael J. Hagan '85 Arena
Home Manager: Billy Lange Away Manager: Dan Engelstad
| NCAAB | 2021/11/12 00:00 | Mount St Marys v Washington University | W | 117-62 |
| NCAAB | 2021/11/09 21:30 | Mount St Marys v Villanova | L | 51-91 |
| NCAAB | 2021/03/18 21:10 | Mount St Marys v Texas Southern | L | 52-60 |
| NCAAB | 2021/03/10 00:00 | Mount St Marys v Bryant | W | 73-68 |
| NCAAB | 2021/03/06 19:00 | Mount St Marys v Wagner | W | 66-60 |
| NCAAB | 2021/02/26 00:00 | Mount St Marys v St Francis PA | W | 72-65 |
| NCAAB | 2021/02/21 19:00 | Mount St Marys v Fairleigh Dickinson | W | 74-61 |
| NCAAB | 2021/02/20 19:00 | Mount St Marys v Fairleigh Dickinson | L | 71-76 |
| NCAAB | 2021/11/10 01:00 | Maryland Eastern-Shore v St Josephs | W | 67-69 |
| NCAAB | 2021/03/04 18:00 | St Josephs v Massachusetts | L | 66-100 |
| NCAAB | 2021/03/03 16:00 | St Josephs v La Salle | W | 72-66 |
| NCAAB | 2021/03/01 23:00 | St Josephs v Richmond | W | 76-73 |
| NCAAB | 2021/02/24 23:00 | Dayton v St Josephs | W | 84-97 |
| NCAAB | 2021/02/20 17:30 | La Salle v St Josephs | W | 82-91 |
| NCAAB | 2021/01/31 00:00 | St Josephs v Duquesne | L | 50-67 |
| NCAAB | 2021/01/26 23:00 | Richmond v St Josephs | L | 79-56 |