Stadium: Amerant Bank Arena
Home Manager: Mike White Away Manager: Brian Gregory
| NCAAB | 2021/12/15 00:00 | Austin Peay v South Florida | W | 51-60 |
| NCAAB | 2021/12/04 00:00 | South Carolina State v South Florida | L | 65-64 |
| NCAAB | 2021/11/30 00:00 | South Florida v Boston College | L | 49-64 |
| NCAAB | 2021/11/25 00:00 | Hampton v South Florida | W | 52-58 |
| NCAAB | 2021/11/20 00:00 | Auburn v South Florida | L | 58-52 |
| NCAAB | 2021/11/16 00:00 | North Carolina A&T v South Florida | W | 54-56 |
| NCAAB | 2021/11/13 17:00 | Georgia Southern v South Florida | L | 53-41 |
| NCAAB | 2021/11/09 22:00 | Bethune Cookman v South Florida | W | 54-75 |
| NCAAB | 2021/12/12 21:30 | Florida Gators v Maryland | L | 68-70 |
| NCAAB | 2021/12/09 00:00 | North Florida v Florida Gators | W | 55-85 |
| NCAAB | 2021/12/06 23:00 | Texas Southern v Florida Gators | L | 69-54 |
| NCAAB | 2021/12/02 01:00 | Florida Gators v Oklahoma | L | 67-74 |
| NCAAB | 2021/11/28 17:00 | Troy v Florida Gators | W | 45-84 |
| NCAAB | 2021/11/25 01:30 | Ohio State v Florida Gators | W | 68-71 |
| NCAAB | 2021/11/23 01:30 | California v Florida Gators | W | 60-80 |
| NCAAB | 2021/11/18 23:00 | Wisc Milwaukee v Florida Gators | W | 45-81 |