Stadium: Yuengling Center
Home Manager: Brian Gregory Away Manager: Tony Madlock
| NCAAB | 2021/11/28 19:00 | The Citadel v South Carolina State | L | 91-79 |
| NCAAB | 2021/11/24 00:00 | USC Upstate v South Carolina State | L | 82-78 |
| NCAAB | 2021/11/19 01:00 | South Carolina State v St. Andrew's | W | 67-53 |
| NCAAB | 2021/11/17 00:00 | South Carolina State v Georgia Bulldogs | L | 60-76 |
| NCAAB | 2021/11/14 00:30 | Lipscomb v South Carolina State | L | 93-81 |
| NCAAB | 2021/11/12 21:00 | Loyola Maryland v South Carolina State | L | 75-65 |
| NCAAB | 2021/11/12 00:00 | South Carolina State v Coll Of Charleston | L | 74-106 |
| NCAAB | 2021/11/10 00:00 | South Carolina State v East Carolina | L | 62-70 |
| NCAAB | 2021/11/30 00:00 | South Florida v Boston College | L | 49-64 |
| NCAAB | 2021/11/25 00:00 | Hampton v South Florida | W | 52-58 |
| NCAAB | 2021/11/20 00:00 | Auburn v South Florida | L | 58-52 |
| NCAAB | 2021/11/16 00:00 | North Carolina A&T v South Florida | W | 54-56 |
| NCAAB | 2021/11/13 17:00 | Georgia Southern v South Florida | L | 53-41 |
| NCAAB | 2021/11/09 22:00 | Bethune Cookman v South Florida | W | 54-75 |
| NCAAB | 2021/03/12 17:00 | South Florida v Wichita State | L | 67-68 |
| NCAAB | 2021/03/11 17:00 | Temple v South Florida | W | 71-73 |