Stadium: Jack Breslin Students Events Center
Home Manager: Tom Izzo Away Manager: Stan Heath
| NCAAB | 2020/11/25 23:00 | Eastern Michigan v Michigan State | L | 67-83 |
| NCAAB | 2019/12/22 00:00 | Eastern Michigan v Michigan State | L | 48-101 |
| NCAAB | 2015/11/24 00:00 | Michigan State v Eastern Michigan | L | 89-65 |
| NCAAB | 2014/12/18 02:00 | Michigan State v Eastern Michigan | L | 66-46 |
| NCAAB | 2011/11/27 12:00 | Eastern Michigan v Michigan State | L | 40-72 |
| NCAAB | 2010/11/12 12:00 | Michigan State v Eastern Michigan | L | 96-66 |
| NCAAB | 2021/11/19 00:00 | Eastern Michigan v Northern Kentucky | L | 73-74 |
| NCAAB | 2021/11/12 23:00 | Illinois St v Eastern Michigan | W | 98-103 |
| NCAAB | 2021/11/09 23:30 | Eastern Michigan v Indiana | L | 62-68 |
| NCAAB | 2021/03/06 00:00 | Eastern Michigan v Western Michigan | W | 64-63 |
| NCAAB | 2021/03/03 00:00 | Eastern Michigan v Ball State | L | 65-100 |
| NCAAB | 2021/02/27 18:00 | Northern Illinois v Eastern Michigan | W | 57-91 |
| NCAAB | 2021/02/25 19:00 | Eastern Michigan v Ohio | L | 67-86 |
| NCAAB | 2021/02/24 00:00 | Bowling Green v Eastern Michigan | L | 82-69 |
| NCAAB | 2021/11/18 00:00 | Michigan State v Butler | W | 73-52 |
| NCAAB | 2021/11/12 23:30 | Western Michigan v Michigan State | W | 46-90 |
| NCAAB | 2021/11/10 00:00 | Kansas v Michigan State | L | 87-74 |
| NCAAB | 2021/03/19 02:19 | UCLA v Michigan State | L | 86-80 |
| NCAAB | 2021/03/11 16:30 | Michigan State v Maryland | L | 57-68 |
| NCAAB | 2021/03/07 21:30 | Michigan v Michigan State | W | 64-70 |
| NCAAB | 2021/03/05 00:00 | Michigan State v Michigan | L | 50-69 |
| NCAAB | 2021/03/03 01:00 | Indiana v Michigan State | W | 58-64 |