Stadium: Joseph J. Gentile Center
Home Manager: Drew Valentine Away Manager: Bryan Mullins
| NCAAB | 2021/03/05 17:00 | Southern Illinois v Loyola Chicago | L | 49-73 |
| NCAAB | 2021/02/27 23:00 | Southern Illinois v Loyola Chicago | L | 58-65 |
| NCAAB | 2021/02/27 02:00 | Southern Illinois v Loyola Chicago | L | 52-60 |
| NCAAB | 2020/01/30 01:00 | Loyola Chicago v Southern Illinois | W | 63-68 |
| NCAAB | 2020/01/17 01:00 | Southern Illinois v Loyola Chicago | L | 48-64 |
| NCAAB | 2019/02/24 21:00 | Loyola Chicago v Southern Illinois | W | 53-63 |
| NCAAB | 2019/01/27 21:00 | Southern Illinois v Loyola Chicago | L | 50-75 |
| NCAAB | 2018/02/22 01:00 | Loyola Chicago v Southern Illinois | L | 75-56 |
| NCAAB | 2022/01/23 01:00 | Southern Illinois v Bradley | L | 62-70 |
| NCAAB | 2022/01/20 01:00 | Indiana State v Southern Illinois | W | 55-63 |
| NCAAB | 2022/01/18 01:00 | Drake v Southern Illinois | L | 60-59 |
| NCAAB | 2022/01/16 01:00 | Northern Iowa v Southern Illinois | L | 69-68 |
| NCAAB | 2022/01/13 01:00 | Southern Illinois v Missouri State | L | 76-81 |
| NCAAB | 2022/01/09 00:00 | Southern Illinois v Valparaiso | W | 63-60 |
| NCAAB | 2021/12/29 01:00 | Grambling State v Southern Illinois | W | 64-75 |
| NCAAB | 2021/12/22 22:00 | Southern Illinois v San Francisco | L | 52-64 |
| NCAAB | 2022/01/22 20:30 | Missouri State v Loyola Chicago | L | 79-69 |
| NCAAB | 2022/01/19 01:00 | Loyola Chicago v Evansville | W | 77-48 |
| NCAAB | 2022/01/16 01:00 | Loyola Chicago v Indiana State | W | 64-56 |
| NCAAB | 2022/01/12 02:00 | Valparaiso v Loyola Chicago | W | 74-81 |
| NCAAB | 2022/01/08 21:00 | Bradley v Loyola Chicago | W | 71-78 |
| NCAAB | 2022/01/06 19:00 | San Francisco v Loyola Chicago | W | 74-79 |
| NCAAB | 2021/12/11 01:00 | Loyola Chicago v Vanderbilt | W | 69-58 |
| NCAAB | 2021/12/08 01:00 | Loyola Chicago v Roosevelt | W | 88-49 |