Stadium: Banterra Center
Home Manager: Bryan Mullins Away Manager: Jesse Shaw
| NCAAB | 2021/12/16 01:00 | SE Missouri State v Southern Illinois | W | 55-80 |
| NCAAB | 2021/12/11 19:00 | Southern Illinois v Tulsa | L | 65-69 |
| NCAAB | 2021/12/05 02:00 | Southern Miss v Southern Illinois | W | 41-66 |
| NCAAB | 2021/12/02 00:00 | Southern Illinois v Evansville | W | 54-52 |
| NCAAB | 2021/11/27 01:00 | Alcorn State v Southern Illinois | W | 59-62 |
| NCAAB | 2021/11/22 22:45 | Creighton v Southern Illinois | L | 66-64 |
| NCAAB | 2021/11/22 01:00 | Northeastern v Southern Illinois | L | 59-47 |
| NCAAB | 2021/11/20 01:00 | Southern Illinois v Colorado | W | 67-63 |
| NCAAB | 2021/02/27 20:00 | Lewis v Maryville | L | 81-58 |
| NCAAB | 2021/02/26 00:30 | Indianapolis v Maryville | W | 56-60 |
| NCAAB | 2021/02/19 00:30 | Maryville v McKendree | L | 58-77 |
| NCAAB | 2021/02/12 00:30 | Lindenwood v Maryville | L | 83-69 |
| NCAAB | 2021/02/05 00:30 | Missouri S&T v Maryville | W | 68-70 |
| NCAAB | 2021/01/30 20:00 | Maryville v Drury | W | 68-59 |
| NCAAB | 2021/01/29 00:30 | Maryville v Southwest Baptist | L | 54-70 |
| NCAAB | 2021/01/27 00:30 | Maryville v Missouri St Louis | L | 68-72 |