Stadium: Minges Coliseum
Home Manager: Joe Dooley Away Manager: Reggie Witherspoon
| NCAAB | 2021/11/10 00:30 | Canisius v Miami Florida | L | 67-77 |
| NCAAB | 2021/03/09 00:00 | Rider v Canisius | L | 78-76 |
| NCAAB | 2021/03/06 00:00 | Canisius v Siena | W | 76-75 |
| NCAAB | 2021/03/05 00:00 | Canisius v Siena | L | 66-73 |
| NCAAB | 2021/02/20 22:00 | Canisius v Fairfield | L | 53-66 |
| NCAAB | 2021/02/19 22:00 | Canisius v Fairfield | W | 80-69 |
| NCAAB | 2021/02/13 18:00 | Canisius v Quinnipiac | W | 89-70 |
| NCAAB | 2021/02/12 18:00 | Canisius v Quinnipiac | W | 74-67 |
| NCAAB | 2021/11/10 00:00 | South Carolina State v East Carolina | W | 62-70 |
| NCAAB | 2021/03/12 00:00 | East Carolina v Central Florida | L | 62-72 |
| NCAAB | 2021/03/07 18:00 | Cincinnati v East Carolina | L | 82-69 |
| NCAAB | 2021/03/05 02:00 | Central Florida v East Carolina | L | 64-60 |
| NCAAB | 2021/02/08 22:00 | SMU v East Carolina | L | 71-56 |
| NCAAB | 2021/02/06 19:00 | East Carolina v Memphis | L | 59-66 |
| NCAAB | 2021/02/03 23:00 | Houston v East Carolina | W | 73-82 |
| NCAAB | 2021/01/30 17:00 | Tulsa v East Carolina | L | 77-68 |