Stadium: G.B. Hodge Center
Home Manager: Dave Dickerson Away Manager: Quinton Ferrell
| NCAAB | 2022/01/08 21:00 | USC Upstate v Presbyterian | L | 82-72 |
| NCAAB | 2021/02/18 22:00 | USC Upstate v Presbyterian | L | 65-51 |
| NCAAB | 2021/02/15 23:00 | USC Upstate v Presbyterian | W | 65-75 |
| NCAAB | 2020/01/31 00:00 | USC Upstate v Presbyterian | L | 77-74 |
| NCAAB | 2019/01/21 21:00 | Presbyterian v USC Upstate | W | 68-59 |
| NCAAB | 2019/01/05 21:00 | USC Upstate v Presbyterian | W | 61-64 |
| NCAAB | 2016/12/14 00:00 | USC Upstate v Presbyterian | L | 76-48 |
| NCAAB | 2015/11/17 00:00 | Presbyterian v USC Upstate | W | 74-73 |
| NCAAB | 2022/02/12 21:30 | Presbyterian v Winthrop | L | 61-65 |
| NCAAB | 2022/02/10 00:00 | High Point v Presbyterian | L | 79-70 |
| NCAAB | 2022/02/08 00:00 | Presbyterian v Hampton | L | 69-74 |
| NCAAB | 2022/02/05 22:00 | Presbyterian v Radford | W | 78-70 |
| NCAAB | 2022/02/03 00:00 | Campbell v Presbyterian | W | 58-64 |
| NCAAB | 2022/01/29 21:00 | UNC Asheville v Presbyterian | L | 68-67 |
| NCAAB | 2022/01/27 00:00 | Presbyterian v Charleston Southern | W | 62-61 |
| NCAAB | 2022/01/22 20:00 | Longwood v Presbyterian | L | 71-70 |
| NCAAB | 2022/02/12 21:00 | UNC Asheville v USC Upstate | L | 83-56 |
| NCAAB | 2022/02/11 00:00 | USC Upstate v Longwood | L | 72-85 |
| NCAAB | 2022/02/05 21:00 | Campbell v USC Upstate | L | 80-71 |
| NCAAB | 2022/02/03 00:00 | USC Upstate v Hampton | W | 85-78 |
| NCAAB | 2022/01/29 21:00 | USC Upstate v North Carolina A&T | W | 84-64 |
| NCAAB | 2022/01/26 23:00 | Winthrop v USC Upstate | L | 95-91 |
| NCAAB | 2022/01/22 21:00 | Charleston Southern v USC Upstate | W | 57-70 |
| NCAAB | 2022/01/20 00:00 | USC Upstate v Gardner Webb | W | 74-61 |