Stadium: Rock Hill Sports & Event Center
Home Manager: Leonard Hamilton Away Manager: Frank Martin
| NCAAB | 2021/12/04 21:00 | Syracuse v Florida State | L | 63-60 |
| NCAAB | 2021/12/01 00:30 | Florida State v Purdue | L | 65-93 |
| NCAAB | 2021/11/25 00:00 | Boston U v Florida State | W | 80-81 |
| NCAAB | 2021/11/23 01:30 | Missouri v Florida State | W | 58-81 |
| NCAAB | 2021/11/21 22:30 | Loyola Marymount v Florida State | W | 45-73 |
| NCAAB | 2021/11/18 01:00 | Tulane v Florida State | W | 54-59 |
| NCAAB | 2021/11/14 18:00 | Florida State v Florida Gators | L | 55-71 |
| NCAAB | 2021/11/11 02:00 | Pennsylvania v Florida State | W | 70-105 |
| NCAAB | 2021/12/05 19:00 | Georgetown v SC Gamecocks | W | 67-80 |
| NCAAB | 2021/12/02 00:00 | SC Gamecocks v Coastal Carolina | L | 56-80 |
| NCAAB | 2021/11/28 19:00 | Rider v SC Gamecocks | W | 58-65 |
| NCAAB | 2021/11/24 00:00 | Wofford v SC Gamecocks | W | 74-85 |
| NCAAB | 2021/11/19 00:00 | UAB v SC Gamecocks | W | 63-66 |
| NCAAB | 2021/11/14 22:00 | Western Kentucky v SC Gamecocks | W | 64-75 |
| NCAAB | 2021/11/13 02:00 | Princeton v SC Gamecocks | L | 66-62 |
| NCAAB | 2021/11/10 00:00 | USC Upstate v SC Gamecocks | W | 60-78 |