Stadium: Winthrop Coliseum
Home Manager: Mark Prosser Away Manager: Dave Dickerson
| NCAAB | 2022/01/26 23:00 | Winthrop v USC Upstate | L | 95-91 |
| NCAAB | 2020/12/13 19:00 | Winthrop v USC Upstate | L | 107-77 |
| NCAAB | 2020/12/12 21:00 | Winthrop v USC Upstate | L | 95-77 |
| NCAAB | 2020/03/05 17:00 | USC Upstate v Winthrop | L | 70-106 |
| NCAAB | 2020/02/27 23:00 | Winthrop v USC Upstate | L | 90-82 |
| NCAAB | 2020/01/24 00:00 | USC Upstate v Winthrop | L | 53-79 |
| NCAAB | 2019/01/19 21:30 | Winthrop v USC Upstate | L | 82-72 |
| NCAAB | 2015/11/25 00:00 | USC Upstate v Winthrop | L | 78-79 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/02/12 21:00 | UNC Asheville v USC Upstate | L | 83-56 |
| NCAAB | 2022/02/11 00:00 | USC Upstate v Longwood | L | 72-85 |
| NCAAB | 2022/02/05 21:00 | Campbell v USC Upstate | L | 80-71 |
| NCAAB | 2022/02/03 00:00 | USC Upstate v Hampton | W | 85-78 |
| NCAAB | 2022/01/29 21:00 | USC Upstate v North Carolina A&T | W | 84-64 |
| NCAAB | 2022/01/26 23:00 | Winthrop v USC Upstate | L | 95-91 |
| NCAAB | 2022/02/19 21:30 | Winthrop v UNC Asheville | W | 84-79 |
| NCAAB | 2022/02/17 00:00 | Winthrop v Gardner Webb | W | 81-70 |
| NCAAB | 2022/02/12 21:30 | Presbyterian v Winthrop | W | 61-65 |
| NCAAB | 2022/02/10 00:00 | Radford v Winthrop | W | 48-58 |
| NCAAB | 2022/02/05 22:30 | Winthrop v Hampton | W | 69-57 |
| NCAAB | 2022/02/04 00:00 | North Carolina A&T v Winthrop | W | 54-64 |
| NCAAB | 2022/01/29 20:00 | Winthrop v Longwood | L | 88-92 |
| NCAAB | 2022/01/26 23:00 | Winthrop v USC Upstate | W | 95-91 |