Stadium: Capital One Arena
Home Manager: Patrick Ewing Away Manager: Carmen Maciariello
| NCAAB | 2021/11/17 00:00 | Yale v Siena | L | 82-54 |
| NCAAB | 2021/11/14 00:00 | Delaware v Siena | L | 83-63 |
| NCAAB | 2021/11/10 00:00 | Siena v St. Bonaventure | L | 47-75 |
| NCAAB | 2021/03/10 22:00 | Iona v Siena | L | 55-52 |
| NCAAB | 2021/03/06 00:00 | Canisius v Siena | L | 76-75 |
| NCAAB | 2021/03/05 00:00 | Canisius v Siena | W | 66-73 |
| NCAAB | 2021/02/28 00:00 | Manhattan v Siena | W | 56-64 |
| NCAAB | 2021/02/26 22:00 | Manhattan v Siena | W | 69-74 |
| NCAAB | 2021/11/17 01:30 | American v Georgetown | W | 57-79 |
| NCAAB | 2021/11/13 19:00 | Dartmouth v Georgetown | L | 69-60 |
| NCAAB | 2021/03/20 16:15 | Georgetown v Colorado | L | 73-96 |
| NCAAB | 2021/03/13 23:30 | Georgetown v Creighton | W | 73-48 |
| NCAAB | 2021/03/12 23:00 | Georgetown v Seton Hall | W | 66-58 |
| NCAAB | 2021/03/11 17:00 | Georgetown v Villanova | W | 72-71 |
| NCAAB | 2021/03/10 20:00 | Marquette v Georgetown | W | 49-68 |
| NCAAB | 2021/03/06 17:00 | Georgetown v Connecticut | L | 82-98 |