Stadium: Jack Breslin Students Events Center
Home Manager: Tom Izzo Away Manager: Micah Shrewsberry
| NCAAB | 2021/02/10 00:00 | Penn State v Michigan State | L | 58-60 |
| NCAAB | 2020/03/04 00:00 | Michigan State v Penn State | L | 79-71 |
| NCAAB | 2020/02/05 01:00 | Penn State v Michigan State | W | 75-70 |
| NCAAB | 2019/01/13 21:30 | Michigan State v Penn State | L | 71-56 |
| NCAAB | 2018/01/31 23:30 | Penn State v Michigan State | L | 68-76 |
| NCAAB | 2017/03/09 19:40 | Penn State v Michigan State | L | 51-78 |
| NCAAB | 2017/01/07 18:00 | Michigan State v Penn State | W | 63-72 |
| NCAAB | 2016/02/28 17:00 | Michigan State v Penn State | L | 88-57 |
| NCAAB | 2021/12/09 00:00 | Wagner v Penn State | W | 54-74 |
| NCAAB | 2021/12/06 00:30 | Ohio State v Penn State | L | 76-64 |
| NCAAB | 2021/12/02 02:15 | Miami Florida v Penn State | L | 63-58 |
| NCAAB | 2021/11/27 20:30 | Penn State v Oregon State | W | 60-45 |
| NCAAB | 2021/11/27 00:00 | Penn State v LSU | L | 63-68 |
| NCAAB | 2021/11/22 23:30 | Cornell v Penn State | W | 74-85 |
| NCAAB | 2021/11/19 00:00 | St. Francis Brooklyn v Penn State | W | 59-74 |
| NCAAB | 2021/11/16 00:00 | Penn State v Massachusetts | L | 56-81 |
| NCAAB | 2021/12/09 02:00 | Michigan State v Minnesota | W | 75-67 |
| NCAAB | 2021/12/04 22:00 | Toledo v Michigan State | W | 68-81 |
| NCAAB | 2021/12/02 00:15 | Louisville v Michigan State | W | 64-73 |
| NCAAB | 2021/11/26 16:00 | Baylor Bears v Michigan State | L | 75-58 |
| NCAAB | 2021/11/25 17:00 | Connecticut v Michigan State | W | 60-64 |
| NCAAB | 2021/11/24 15:00 | Loyola Chicago v Michigan State | W | 61-63 |
| NCAAB | 2021/11/20 22:00 | Eastern Michigan v Michigan State | W | 59-83 |
| NCAAB | 2021/11/18 00:00 | Michigan State v Butler | W | 73-52 |