Stadium: Lawrence Joel Veterans Memorial Coliseum
Home Manager: Steve Forbes Away Manager: Dave Dickerson
| NCAAB | 2021/12/04 23:00 | Western Carolina v USC Upstate | L | 78-73 |
| NCAAB | 2021/12/01 21:00 | North Carolina Central v USC Upstate | L | 67-65 |
| NCAAB | 2021/11/27 21:00 | Furman v USC Upstate | L | 87-77 |
| NCAAB | 2021/11/24 00:00 | USC Upstate v South Carolina State | W | 82-78 |
| NCAAB | 2021/11/19 00:00 | USC Upstate v East Tenn St | L | 43-56 |
| NCAAB | 2021/11/15 23:00 | USC Upstate v St. Andrew's | W | 96-43 |
| NCAAB | 2021/11/13 00:00 | USC Upstate v Charlotte U | L | 64-76 |
| NCAAB | 2021/11/10 00:00 | USC Upstate v SC Gamecocks | L | 60-78 |
| NCAAB | 2021/12/04 19:00 | Wake Forest v Virginia Tech | W | 80-61 |
| NCAAB | 2021/12/01 02:00 | Northwestern v Wake Forest | W | 73-77 |
| NCAAB | 2021/11/28 00:00 | LSU v Wake Forest | L | 75-61 |
| NCAAB | 2021/11/27 02:30 | Oregon State v Wake Forest | W | 77-80 |
| NCAAB | 2021/11/24 01:00 | Kennesaw State v Wake Forest | W | 61-92 |
| NCAAB | 2021/11/20 21:00 | North Carolina A&T v Wake Forest | W | 63-87 |
| NCAAB | 2021/11/18 00:00 | Charleston Southern v Wake Forest | W | 59-95 |
| NCAAB | 2021/11/13 00:30 | Western Carolina v Wake Forest | W | 75-87 |