Stadium: Imperial Arena
Home Manager: Tom Izzo Away Manager: Drew Valentine
| NCAAB | 2014/11/22 00:00 | Michigan State v Loyola Chicago | L | 87-52 |
| NCAAB | 2002/12/17 12:00 | Michigan State v Loyola Chicago | L | 80-54 |
| NCAAB | 2021/11/20 21:00 | Illinois-Chicago v Loyola Chicago | W | 63-80 |
| NCAAB | 2021/11/17 01:00 | Chicago St v Loyola Chicago | W | 56-92 |
| NCAAB | 2021/11/13 19:00 | Florida Gulf Coast v Loyola Chicago | W | 77-89 |
| NCAAB | 2021/11/10 01:00 | Coppin State v Loyola Chicago | W | 45-103 |
| NCAAB | 2021/03/27 18:40 | Oregon State v Loyola Chicago | L | 65-58 |
| NCAAB | 2021/03/21 16:10 | Loyola Chicago v Illinois | W | 71-58 |
| NCAAB | 2021/03/19 20:15 | Georgia Tech v Loyola Chicago | W | 60-71 |
| NCAAB | 2021/03/07 19:00 | Drake v Loyola Chicago | W | 65-75 |
| NCAAB | 2021/11/20 22:00 | Eastern Michigan v Michigan State | W | 59-83 |
| NCAAB | 2021/11/18 00:00 | Michigan State v Butler | W | 73-52 |
| NCAAB | 2021/11/12 23:30 | Western Michigan v Michigan State | W | 46-90 |
| NCAAB | 2021/11/10 00:00 | Kansas v Michigan State | L | 87-74 |
| NCAAB | 2021/03/19 02:19 | UCLA v Michigan State | L | 86-80 |
| NCAAB | 2021/03/11 16:30 | Michigan State v Maryland | L | 57-68 |
| NCAAB | 2021/03/07 21:30 | Michigan v Michigan State | W | 64-70 |
| NCAAB | 2021/03/05 00:00 | Michigan State v Michigan | L | 50-69 |