Stadium: Jack Breslin Students Events Center
Home Manager: Tom Izzo Away Manager: Tubby Smith
| NCAAB | 2021/12/21 20:30 | Florida Atlantic v High Point | W | 52-55 |
| NCAAB | 2021/12/18 19:00 | UNC Wilmington v High Point | L | 71-69 |
| NCAAB | 2021/12/11 00:00 | High Point v South Carolina State | L | 66-67 |
| NCAAB | 2021/12/08 00:00 | High Point v Guilford | W | 64-59 |
| NCAAB | 2021/12/05 00:00 | High Point v Elon | W | 83-77 |
| NCAAB | 2021/12/01 00:00 | Furman v High Point | L | 74-70 |
| NCAAB | 2021/11/27 19:00 | Chowan v High Point | W | 60-90 |
| NCAAB | 2021/11/21 19:00 | Georgia State v High Point | L | 74-66 |
| NCAAB | 2021/12/22 00:30 | Michigan State v Oakland | W | 90-78 |
| NCAAB | 2021/12/11 19:00 | Penn State v Michigan State | W | 64-80 |
| NCAAB | 2021/12/09 02:00 | Michigan State v Minnesota | W | 75-67 |
| NCAAB | 2021/12/04 22:00 | Toledo v Michigan State | W | 68-81 |
| NCAAB | 2021/12/02 00:15 | Louisville v Michigan State | W | 64-73 |
| NCAAB | 2021/11/26 16:00 | Baylor Bears v Michigan State | L | 75-58 |
| NCAAB | 2021/11/25 17:00 | Connecticut v Michigan State | W | 60-64 |
| NCAAB | 2021/11/24 15:00 | Loyola Chicago v Michigan State | W | 61-63 |