Stadium: The Buc Dome
Home Manager: Barclay Radebaugh Away Manager: Dave Dickerson
| NCAAB | 2022/01/22 21:00 | Charleston Southern v USC Upstate | W | 57-70 |
| NCAAB | 2020/02/10 23:00 | Charleston Southern v USC Upstate | W | 52-66 |
| NCAAB | 2020/01/03 00:30 | USC Upstate v Charleston Southern | L | 75-89 |
| NCAAB | 2019/03/06 00:00 | USC Upstate v Charleston Southern | L | 52-71 |
| NCAAB | 2019/02/22 00:30 | USC Upstate v Charleston Southern | L | 60-92 |
| NCAAB | 2019/02/02 21:30 | Charleston Southern v USC Upstate | L | 90-71 |
| NCAAB | 2017/11/18 19:00 | USC Upstate v Charleston Southern | L | 72-82 |
| NCAAB | 2016/11/19 22:30 | Charleston Southern v USC Upstate | W | 77-79 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/02/12 21:00 | UNC Asheville v USC Upstate | L | 83-56 |
| NCAAB | 2022/02/11 00:00 | USC Upstate v Longwood | L | 72-85 |
| NCAAB | 2022/02/05 21:00 | Campbell v USC Upstate | L | 80-71 |
| NCAAB | 2022/02/03 00:00 | USC Upstate v Hampton | W | 85-78 |
| NCAAB | 2022/01/29 21:00 | USC Upstate v North Carolina A&T | W | 84-64 |
| NCAAB | 2022/01/26 23:00 | Winthrop v USC Upstate | L | 95-91 |
| NCAAB | 2022/01/22 21:00 | Charleston Southern v USC Upstate | W | 57-70 |
| NCAAB | 2022/02/17 00:00 | UNC Asheville v Charleston Southern | L | 85-66 |
| NCAAB | 2022/02/12 19:00 | Charleston Southern v Gardner Webb | L | 65-82 |
| NCAAB | 2022/02/10 00:00 | Charleston Southern v North Carolina A&T | L | 51-62 |
| NCAAB | 2022/02/08 00:00 | Charleston Southern v Toccoa Falls | W | 97-60 |
| NCAAB | 2022/02/05 22:30 | Longwood v Charleston Southern | L | 69-67 |
| NCAAB | 2022/02/02 23:30 | Charleston Southern v Radford | L | 52-64 |
| NCAAB | 2022/01/29 22:30 | Hampton v Charleston Southern | L | 78-74 |
| NCAAB | 2022/01/27 00:00 | Presbyterian v Charleston Southern | L | 62-61 |