Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Leonard Hamilton
| NCAAB | 2021/01/23 20:00 | Clemson v Florida State | W | 61-80 |
| NCAAB | 2020/12/30 00:00 | Florida State v Clemson | L | 67-77 |
| NCAAB | 2020/02/29 19:00 | Florida State v Clemson | L | 69-70 |
| NCAAB | 2019/12/08 19:00 | Clemson v Florida State | W | 53-72 |
| NCAAB | 2019/02/20 02:00 | Florida State v Clemson | W | 77-64 |
| NCAAB | 2019/01/23 00:00 | Clemson v Florida State | W | 68-77 |
| NCAAB | 2018/03/01 02:00 | Florida State v Clemson | L | 63-76 |
| NCAAB | 2018/02/15 00:00 | Clemson v Florida State | W | 79-81 |
| NCAAB | 2022/01/29 20:00 | Virginia Tech v Florida State | L | 85-72 |
| NCAAB | 2022/01/27 02:00 | Florida State v Georgia Tech | L | 61-75 |
| NCAAB | 2022/01/22 19:00 | Florida State v Miami Florida | W | 61-60 |
| NCAAB | 2022/01/20 17:00 | North Florida v Florida State | W | 73-86 |
| NCAAB | 2022/01/19 02:00 | Duke v Florida State | W | 78-79 |
| NCAAB | 2022/01/15 20:00 | Florida State v Syracuse | W | 76-71 |
| NCAAB | 2022/01/12 01:00 | Miami Florida v Florida State | W | 64-65 |
| NCAAB | 2022/01/09 01:00 | Louisville v Florida State | W | 70-79 |
| NCAAB | 2022/01/26 00:00 | Clemson v Duke | L | 69-71 |
| NCAAB | 2022/01/22 23:00 | Pittsburgh v Clemson | W | 48-75 |
| NCAAB | 2022/01/19 02:00 | Clemson v Syracuse | L | 78-91 |
| NCAAB | 2022/01/15 23:30 | Boston College v Clemson | L | 70-68 |
| NCAAB | 2022/01/13 00:00 | Clemson v Notre Dame | L | 56-72 |
| NCAAB | 2022/01/08 17:00 | Clemson v NC State | W | 70-65 |
| NCAAB | 2022/01/05 02:00 | Virginia v Clemson | L | 75-65 |
| NCAAB | 2021/12/23 00:00 | Clemson v Virginia | W | 67-50 |