Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Jack Owens
| NCAAB | 2021/12/04 18:00 | Miami Ohio v Indiana State | L | 68-69 |
| NCAAB | 2021/12/02 00:00 | Cincinnati v Miami Ohio | L | 59-58 |
| NCAAB | 2021/11/27 20:00 | Miami Ohio v Western Illinois | L | 67-79 |
| NCAAB | 2021/11/24 00:00 | Miami Ohio v Defiance | W | 99-47 |
| NCAAB | 2021/11/20 19:00 | Miami Ohio v Heidelberg | W | 90-45 |
| NCAAB | 2021/11/18 00:00 | Stetson v Miami Ohio | W | 65-80 |
| NCAAB | 2021/11/13 19:00 | Lamar v Miami Ohio | W | 75-104 |
| NCAAB | 2021/11/10 00:30 | Miami Ohio v Georgia Tech | W | 72-69 |
| NCAAB | 2021/12/11 19:00 | Drake v Clemson | W | 80-90 |
| NCAAB | 2021/12/04 17:00 | Clemson v Miami Florida | L | 75-80 |
| NCAAB | 2021/12/01 02:00 | Clemson v Rutgers | L | 64-74 |
| NCAAB | 2021/11/26 19:00 | Charleston Southern v Clemson | W | 59-91 |
| NCAAB | 2021/11/21 22:00 | Clemson v West Virginia | L | 59-66 |
| NCAAB | 2021/11/19 19:30 | St. Bonaventure v Clemson | L | 68-65 |
| NCAAB | 2021/11/18 21:30 | Clemson v Temple | W | 75-48 |
| NCAAB | 2021/11/16 00:00 | Bryant v Clemson | W | 70-93 |