Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Barclay Radebaugh
| NCAAB | 2018/12/19 00:00 | Charleston Southern v Clemson | L | 51-78 |
| NCAAB | 2006/11/24 12:00 | Clemson v Charleston Southern | L | 74-50 |
| NCAAB | 2005/11/26 12:00 | Charleston Southern v Clemson | L | 56-68 |
| NCAAB | 2004/12/11 12:00 | Clemson v Charleston Southern | L | 73-55 |
| NCAAB | 2021/11/23 00:00 | Charleston Southern v Georgia Tech | L | 70-85 |
| NCAAB | 2021/11/20 20:00 | Charleston Southern v Bob Jones University | W | 119-63 |
| NCAAB | 2021/11/18 00:00 | Charleston Southern v Wake Forest | L | 59-95 |
| NCAAB | 2021/11/13 00:00 | Charleston Southern v Mississippi | L | 68-93 |
| NCAAB | 2021/11/10 00:00 | Charleston Southern v Johnson & Wales (NC) | W | 118-71 |
| NCAAB | 2021/02/22 23:00 | Charleston Southern v Presbyterian | W | 78-77 |
| NCAAB | 2021/02/19 23:00 | Longwood v Charleston Southern | L | 64-58 |
| NCAAB | 2021/02/19 00:00 | Longwood v Charleston Southern | L | 70-62 |
| NCAAB | 2021/11/21 22:00 | Clemson v West Virginia | L | 59-66 |
| NCAAB | 2021/11/19 19:30 | St. Bonaventure v Clemson | L | 68-65 |
| NCAAB | 2021/11/18 21:30 | Clemson v Temple | W | 75-48 |
| NCAAB | 2021/11/16 00:00 | Bryant v Clemson | W | 70-93 |
| NCAAB | 2021/11/13 00:00 | Wofford v Clemson | W | 68-76 |
| NCAAB | 2021/11/10 00:00 | Presbyterian v Clemson | W | 53-64 |
| NCAAB | 2021/03/20 01:20 | Rutgers v Clemson | L | 60-56 |
| NCAAB | 2021/03/10 19:30 | Miami Florida v Clemson | L | 67-64 |