Stadium: Covelli Center
Home Manager: Brian Barone Away Manager: Greg Paulus
| NCAAB | 2021/11/13 00:00 | Niagara v Ohio State | L | 74-84 |
| NCAAB | 2021/11/10 00:30 | Niagara v Xavier | L | 60-63 |
| NCAAB | 2021/11/01 23:00 | Niagara v Cazenovia | W | 95-55 |
| NCAAB | 2021/03/12 22:30 | Iona v Niagara | L | 70-64 |
| NCAAB | 2021/03/12 00:30 | Niagara v Marist | W | 67-62 |
| NCAAB | 2021/02/21 17:00 | Siena v Niagara | L | 68-66 |
| NCAAB | 2021/02/20 17:00 | Siena v Niagara | W | 62-64 |
| NCAAB | 2021/01/30 21:00 | Niagara v Monmouth | W | 83-74 |
| NCAAB | 2021/11/16 00:00 | SIU Edwardsville v Knox | W | 75-37 |
| NCAAB | 2021/11/13 01:00 | SIU Edwardsville v Chicago St | L | 56-67 |
| NCAAB | 2021/11/10 01:30 | SIU Edwardsville v Marquette | L | 77-88 |
| NCAAB | 2021/03/04 01:00 | SIU Edwardsville v Belmont | L | 61-78 |
| NCAAB | 2021/02/27 23:00 | SE Missouri State v SIU Edwardsville | L | 69-63 |
| NCAAB | 2021/02/25 23:00 | Tennessee Martin v SIU Edwardsville | W | 53-66 |
| NCAAB | 2021/02/22 23:00 | Morehead State v SIU Edwardsville | L | 56-48 |
| NCAAB | 2021/02/21 01:30 | SIU Edwardsville v Murray State | L | 62-89 |