Stadium: Wolstein Center
Home Manager: Dennis Gates Away Manager: Reggie Witherspoon
| NCAAB | 2021/11/14 22:00 | Canisius v St. Bonaventure | L | 60-69 |
| NCAAB | 2021/11/13 00:00 | Canisius v East Carolina | L | 71-83 |
| NCAAB | 2021/11/10 00:30 | Canisius v Miami Florida | L | 67-77 |
| NCAAB | 2021/03/09 00:00 | Rider v Canisius | L | 78-76 |
| NCAAB | 2021/03/06 00:00 | Canisius v Siena | W | 76-75 |
| NCAAB | 2021/03/05 00:00 | Canisius v Siena | L | 66-73 |
| NCAAB | 2021/02/20 22:00 | Canisius v Fairfield | L | 53-66 |
| NCAAB | 2021/02/19 22:00 | Canisius v Fairfield | W | 80-69 |
| NCAAB | 2021/11/17 00:00 | Cleveland State v Edinboro | W | 75-61 |
| NCAAB | 2021/11/14 00:00 | Ohio v Cleveland State | L | 67-56 |
| NCAAB | 2021/11/10 02:00 | Cleveland State v BYU | L | 59-69 |
| NCAAB | 2021/03/19 23:15 | Cleveland State v Houston | L | 56-87 |
| NCAAB | 2021/03/10 00:00 | Oakland v Cleveland State | W | 69-80 |
| NCAAB | 2021/03/08 23:30 | Wisc Milwaukee v Cleveland State | W | 65-71 |
| NCAAB | 2021/03/03 00:00 | IPFW v Cleveland State | W | 104-108 |
| NCAAB | 2021/02/20 22:00 | Cleveland State v IPFW | W | 67-55 |