Stadium: Cintas Center
Home Manager: Travis Steele Away Manager: Tony Barbee
| NCAAB | 2021/11/30 00:00 | Central Michigan v Kentucky | L | 57-85 |
| NCAAB | 2021/11/24 00:00 | Central Michigan v Bellarmine | L | 69-76 |
| NCAAB | 2021/11/23 04:00 | Gonzaga v Central Michigan | L | 107-54 |
| NCAAB | 2021/11/16 01:00 | Central Michigan v Eastern Illinois | W | 62-61 |
| NCAAB | 2021/11/13 23:00 | Central Michigan v DePaul | L | 66-99 |
| NCAAB | 2021/11/10 01:00 | Central Michigan v Missouri | L | 68-78 |
| NCAAB | 2021/03/05 22:00 | Northern Illinois v Central Michigan | L | 79-74 |
| NCAAB | 2021/03/02 22:00 | Toledo v Central Michigan | W | 79-81 |
| NCAAB | 2021/11/27 00:00 | Xavier v Virginia Tech | W | 59-58 |
| NCAAB | 2021/11/25 00:00 | Xavier v Iowa State | L | 70-82 |
| NCAAB | 2021/11/21 17:00 | Norfolk State v Xavier | W | 48-88 |
| NCAAB | 2021/11/18 23:30 | Ohio State v Xavier | W | 65-71 |
| NCAAB | 2021/11/12 23:30 | Kent State v Xavier | W | 59-73 |
| NCAAB | 2021/11/10 00:30 | Niagara v Xavier | W | 60-63 |
| NCAAB | 2021/03/10 23:00 | Butler v Xavier | L | 70-69 |
| NCAAB | 2021/03/07 02:00 | Xavier v Marquette | L | 59-66 |