Stadium: Barclays Center
Home Manager: T.J. Otzelberger Away Manager: Travis Steele
| NCAAB | 2005/01/03 12:00 | Xavier v Iowa State | W | 72-59 |
| NCAAB | 2003/12/23 12:00 | Iowa State v Xavier | L | 68-61 |
| NCAAB | 2021/11/21 17:00 | Norfolk State v Xavier | W | 48-88 |
| NCAAB | 2021/11/18 23:30 | Ohio State v Xavier | W | 65-71 |
| NCAAB | 2021/11/12 23:30 | Kent State v Xavier | W | 59-73 |
| NCAAB | 2021/11/10 00:30 | Niagara v Xavier | W | 60-63 |
| NCAAB | 2021/03/10 23:00 | Butler v Xavier | L | 70-69 |
| NCAAB | 2021/03/07 02:00 | Xavier v Marquette | L | 59-66 |
| NCAAB | 2021/03/03 00:00 | Xavier v Georgetown | L | 66-72 |
| NCAAB | 2021/02/27 22:00 | Creighton v Xavier | W | 69-77 |
| NCAAB | 2021/11/21 23:00 | Grambling State v Iowa State | W | 47-82 |
| NCAAB | 2021/11/17 01:00 | Alabama State v Iowa State | W | 60-68 |
| NCAAB | 2021/11/13 01:00 | Oregon State v Iowa State | W | 50-60 |
| NCAAB | 2021/11/10 01:00 | Kennesaw State v Iowa State | W | 73-84 |
| NCAAB | 2021/03/11 02:30 | Iowa State v Oklahoma | L | 73-79 |
| NCAAB | 2021/03/06 22:00 | Iowa State v Kansas State | L | 56-61 |
| NCAAB | 2021/03/05 00:00 | Iowa State v Texas Tech | L | 54-81 |
| NCAAB | 2021/03/03 00:00 | Texas v Iowa State | L | 81-67 |