Stadium: Lantz Arena
Home Manager: Marty Simmons Away Manager: Brian Barone
| NCAAB | 2021/02/02 23:00 | Eastern Illinois v SIU Edwardsville | L | 70-61 |
| NCAAB | 2021/01/27 01:00 | SIU Edwardsville v Eastern Illinois | W | 87-74 |
| NCAAB | 2020/02/29 20:00 | Eastern Illinois v SIU Edwardsville | L | 70-52 |
| NCAAB | 2020/02/14 01:30 | SIU Edwardsville v Eastern Illinois | W | 76-74 |
| NCAAB | 2019/02/14 23:30 | Eastern Illinois v SIU Edwardsville | L | 79-65 |
| NCAAB | 2019/01/05 21:15 | SIU Edwardsville v Eastern Illinois | L | 81-84 |
| NCAAB | 2018/02/24 21:15 | SIU Edwardsville v Eastern Illinois | L | 56-68 |
| NCAAB | 2018/02/09 01:00 | Eastern Illinois v SIU Edwardsville | L | 78-74 |
| NCAAB | 2022/01/08 21:00 | Murray State v SIU Edwardsville | L | 74-69 |
| NCAAB | 2021/12/22 01:00 | SIU Edwardsville v South Alabama | L | 69-84 |
| NCAAB | 2021/12/19 19:00 | William Woods v SIU Edwardsville | W | 29-84 |
| NCAAB | 2021/12/12 20:00 | Kansas City v SIU Edwardsville | W | 56-60 |
| NCAAB | 2021/12/09 01:00 | IPFW v SIU Edwardsville | W | 59-80 |
| NCAAB | 2021/12/04 20:00 | SIU Edwardsville v Bradley | L | 55-80 |
| NCAAB | 2021/12/01 01:00 | SIU Edwardsville v Nebraska Omaha | W | 75-65 |
| NCAAB | 2021/11/27 23:00 | SIU Edwardsville v Creighton | L | 65-70 |
| NCAAB | 2021/12/30 00:00 | Eastern Illinois v Morehead State | L | 50-63 |
| NCAAB | 2021/12/22 00:00 | Eastern Illinois v Ball State | L | 55-75 |
| NCAAB | 2021/12/18 20:00 | Eastern Illinois v Western Illinois | L | 54-71 |
| NCAAB | 2021/12/11 21:00 | Eastern Illinois v Butler | L | 54-66 |
| NCAAB | 2021/12/08 01:00 | Eastern Illinois v Missouri | L | 44-72 |
| NCAAB | 2021/12/04 20:00 | Eastern Illinois v North Park | W | 76-71 |
| NCAAB | 2021/12/02 01:00 | Eastern Illinois v Northern Illinois | L | 45-55 |
| NCAAB | 2021/11/28 19:00 | Evansville v Eastern Illinois | L | 70-54 |