Stadium: Welsh-Ryan Arena
Home Manager: Chris Collins Away Manager: Matt Brock
| NCAAB | 2021/12/12 21:00 | NJIT v Northwestern | W | 52-70 |
| NCAAB | 2021/12/05 17:00 | Northwestern v Maryland | W | 67-61 |
| NCAAB | 2021/12/01 02:00 | Northwestern v Wake Forest | L | 73-77 |
| NCAAB | 2021/11/23 22:00 | Georgia Bulldogs v Northwestern | W | 62-78 |
| NCAAB | 2021/11/23 02:30 | Providence v Northwestern | L | 77-72 |
| NCAAB | 2021/11/19 02:00 | Fairleigh Dickinson v Northwestern | W | 46-82 |
| NCAAB | 2021/11/17 01:00 | New Orleans v Northwestern | W | 67-83 |
| NCAAB | 2021/11/12 21:00 | High Point v Northwestern | W | 60-95 |
| NCAAB | 2021/02/27 20:30 | Illinois Springfield v Missouri S&T | W | 80-71 |
| NCAAB | 2021/02/20 20:00 | Southwest Baptist v Illinois Springfield | L | 73-60 |
| NCAAB | 2021/02/17 00:30 | McKendree v Illinois Springfield | L | 66-42 |
| NCAAB | 2021/02/13 20:30 | Illinois Springfield v William Jewel | L | 68-73 |
| NCAAB | 2021/02/12 00:00 | Illinois Springfield v Truman State | L | 63-72 |
| NCAAB | 2021/02/06 20:15 | Quincy University v Illinois Springfield | L | 75-64 |
| NCAAB | 2021/01/30 20:00 | Lewis v Illinois Springfield | W | 75-78 |
| NCAAB | 2021/01/29 00:30 | Indianapolis v Illinois Springfield | L | 55-43 |