Stadium: Moody Coliseum
Home Manager: Tim Jankovich Away Manager: Jerry Stackhouse
| NCAAB | 2021/11/30 01:00 | Mississippi Valley State v Vanderbilt | W | 36-75 |
| NCAAB | 2021/11/25 02:00 | Vanderbilt v Pittsburgh | W | 68-52 |
| NCAAB | 2021/11/21 01:00 | Winthrop v Vanderbilt | W | 63-77 |
| NCAAB | 2021/11/18 01:00 | VA Commonwealth v Vanderbilt | L | 48-37 |
| NCAAB | 2021/11/15 01:00 | Texas State v Vanderbilt | W | 60-79 |
| NCAAB | 2021/11/11 01:00 | Alabama State v Vanderbilt | W | 72-91 |
| NCAAB | 2021/03/11 19:30 | Vanderbilt v Florida Gators | L | 63-69 |
| NCAAB | 2021/03/11 00:00 | Texas A&M v Vanderbilt | W | 68-79 |
| NCAAB | 2021/12/02 01:00 | UNLV v SMU | W | 64-83 |
| NCAAB | 2021/11/28 20:00 | UL Monroe v SMU | W | 67-74 |
| NCAAB | 2021/11/25 01:00 | Sam Houston State v SMU | W | 66-75 |
| NCAAB | 2021/11/22 23:00 | Loyola Marymount v SMU | L | 76-70 |
| NCAAB | 2021/11/22 01:00 | SMU v Missouri | L | 75-80 |
| NCAAB | 2021/11/19 01:00 | SE Louisiana v SMU | W | 61-78 |
| NCAAB | 2021/11/16 01:00 | Northwestern State v SMU | W | 48-95 |
| NCAAB | 2021/11/13 04:00 | SMU v Oregon | L | 63-86 |