Stadium: JSerra Pavilion
Home Manager: John Smith Away Manager: Austin Claunch
| NCAAB | 2021/11/20 02:00 | Cal Poly SLO v Santa Clara | L | 57-87 |
| NCAAB | 2021/11/16 03:00 | Sacramento State v Cal Poly SLO | L | 58-57 |
| NCAAB | 2021/11/12 22:00 | North Dakota State v Cal Poly SLO | L | 60-57 |
| NCAAB | 2021/11/10 03:00 | Cal Poly SLO v Westcliff University | W | 86-53 |
| NCAAB | 2021/03/12 01:00 | Cal Poly SLO v UC Irvine | L | 51-58 |
| NCAAB | 2021/03/10 02:00 | Cal Poly SLO v CS Fullerton | W | 87-82 |
| NCAAB | 2021/03/07 01:00 | Cal Poly SLO v UC Santa Barbara | L | 54-70 |
| NCAAB | 2021/03/06 01:00 | Cal Poly SLO v UC Santa Barbara | L | 57-71 |
| NCAAB | 2021/11/19 01:00 | Nicholls State v TCU | L | 50-63 |
| NCAAB | 2021/11/15 17:00 | Nicholls State v Baylor Bears | L | 60-89 |
| NCAAB | 2021/11/13 18:00 | Nicholls State v Carver | W | 101-44 |
| NCAAB | 2021/11/13 01:00 | Nicholls State v Carver | W | 120-52 |
| NCAAB | 2021/11/10 01:00 | Nicholls State v Northern Iowa | W | 62-58 |
| NCAAB | 2021/03/14 02:30 | Abilene Christian v Nicholls State | L | 79-45 |
| NCAAB | 2021/03/12 23:00 | Northwestern State v Nicholls State | W | 76-88 |
| NCAAB | 2021/03/05 00:30 | Nicholls State v McNeese State | W | 80-67 |